Abstract
We investigated the involvement of cutaneous structures in specific linear migration pathways of technetium-99m pertechnetate hypodermically injected at points of low electrical resistance in the metacarpus of male beagles. Skin-deep incisions were made in the front or back legs on either the same side as the 99mTc injection or on the opposite side. Incisions in the back legs did not affect the migration pattern. Incisions in the front legs before the injection of 99mTc prevented tracer migration. After the injection of 99mTc, incisions in the front contralateral leg caused sudden cessation of the migration, while incisions in the ipsilateral leg caused immediate disappearance of the pathway previously observed. Radioactivity was not detected in flaps obtained from the skin overlying the migration pathway or from the corresponding area of the contralateral leg. In conclusion, the specific linear migration pathways of 99mTc hypodermically injected at points of low electrical resistance cannot be explained by any known biological function. Although the migration of 99mTc does not seem to be strongly linked to any cutaneous structure, the skin overlying the radioactive pathway and the corresponding area of the contralateral leg must be intact if tracer migration is to take place.
Similar content being viewed by others
References
Niboyet JH. La moindre résistance à l'electricité de surfaces punctiformes et de trajects cutanés concordant avec les points et méridiens, bases de l'acupuncture. Gap: Luis Jean, 1963.
De Vernejoul P, Darras JC, Albarède P, et al. Approche isotopique de la visualization des méridiens d'acupuncture. Inn Tech Biol Med 1984; 5:465–472.
Kovacs FM, Gotzens V, Garcia A, et al. Experimental study on radioactive pathways of hypodermically injected technetium-99m. J Nucl Med 1992; 33:403–407.
Kovacs FM, Gotzens V, García A, Garcia F, Mufraggi N, Prandi D. Acupuncture and radioactive pathways of hypodermically injected technetium-99m. J Nucl Med 1992; 33:2060.
Scott JA. Anatomic divisions. J Nucl Med 1992; 33:407–409.
Bergqvist L, Strand SE, Persson BRR. Particle sizing and biokinetics of interstitial lymphoscintigraphic agents. Semin Nucl Med 1983; 13:9–19.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kovacs, F.M., Gotzens, V., García, A. et al. Kinetics of hypodermically injected technetium-99m and correlation with cutaneous structures: an experimental study in dogs. Eur J Nucl Med 20, 585–590 (1993). https://doi.org/10.1007/BF00176552
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF00176552