Summary
A high yielding strain of Penicillium chrysogenum was mutated with EMS and investigated for selective effects of semi-continuous fermentations. Preferential growth of a class of mutants with different colony type and having reduced ability to utilize side-chain precursor led to reduced Pen V synthesis by the heterogeneous mycelial population.
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Egen, R.C., Pathak, S.G. Reduced utilization of side-chain precursor for penicillin biosynthesis by mutants of Penicillium chrysogenum . Biotechnol Lett 2, 321–326 (1980). https://doi.org/10.1007/BF00172645
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DOI: https://doi.org/10.1007/BF00172645