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The use of technetium-99m methoxyisobutylisonitrile breast scintigraphy to evaluate palpable breast masses

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Abstract

Thirty-eight female patients (age range: 31–79 years) with breast masses underwent technetium-99m methoxyisobutylisonitrile (99mTc-MIBI) breast scintigraphy in order to assess the value of this technique in the detection of breast carcinomas and in their differentiation from benign breast masses. The results showed that 27 of the 32 cases of breast carcinoma were detected by 99mTc-MIBI breast scintigraphy. In contrast, none of the six benign lesions could be detected by this method. The diagnostic sensitivity, specificity and accuracy were 84%, 100% and 87%, respectively, in the differentiation of malignant and benign breast masses. In conclusion, we consider 99mTc-MIBI breast scintigraphy is useful in distinguishing malignancies from benign breast masses.

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References

  1. Piwnica-Worms D, Kronauge JF, Chin ML. Uptake and retention of hexakis (2-methoxyisobutyl isonitrile) technetium (I) in cultured chick myocardial cells. Mitchondrial and plasma membrane potential dependence. Circulation 1990; 82: 1826–1838.

    Google Scholar 

  2. Beller GA, Watson DD. Physiological basis of myocardial perfusion imaging with the technetium 99m agents. Semin Nucl Med 1991; 21: 173–181.

    Google Scholar 

  3. Wackers FJ-Th, Berman DS, Maddahi J, et al. Technetium99m-haxakis-2-methoxyisobutyl isonitrile: human biodistribution, dosimetry, safety, and preliminary comparison to thallium-201 for myocardial perfusion imaging. J Nucl Med 1989; 30: 301–311.

    Google Scholar 

  4. Baillet GY, Mena IG, Kuperus JH, et al. Simultaneous technetium-99m-MIBI angiography and myocardial perfusion imaging. J Nucl Med 1989; 30: 38–44.

    Google Scholar 

  5. Caner B, Kitapci M, Aras T, Erbengi G, Ugur O, Bekdik C. Increased accumulation of hexakis (2-methoxyisobutylisonitrile) technetium (1) in osteosarcoma and its metastatic lymph nodes. J Nucl Med 1991; 32: 1977–1978.

    Google Scholar 

  6. O'Tuama LA, Packard AB, Treves ST. SPECT imaging of pedriatic brain tumor with hexakis (methoxyisobutylisonitrile) technetium (I). J Nucl Med 1990; 31: 2040–2041.

    Google Scholar 

  7. Kao CH, Wang SJ, Lin WY, Hsu CY, Liao SQ, Yeh SH. Detection of nasopharyngeal carcinoma using Tc-99m metboxyisobutylisonitrile SPECT. Nucl Med Commun 1993; 14: 41–46.

    Google Scholar 

  8. Hassan IM, Sahweil A, Constantinides C, et al. Uptake and kinetics of Tc-99m hexakis 2-methoxy isobutyl isonitrile in benign and malignant lesions in the lungs. Clin Nucl Med 1989; 14: 333–340.

    Google Scholar 

  9. Kao CH, Wang SJ, Lin WY, Hsu CY, Liao SQ, Yeh SH. Differentiation of single solid lesions in the lungs by means of single-photon emission tomography with technetium-99m methoxyisobutylisonitrile. Eur J Nucl Med 1993; 20: 249–254.

    Google Scholar 

  10. Mann BD, Giuliano AE, Bassett LW et al. Delayed diagnosis of breast cancer as a result of normal mammograms. Arch Surg 1983; 118: 23–25.

    Google Scholar 

  11. Holland R, Jan HC, Hendricks L, Mravunac M. Mammographically occult breast cancer: a pathologic and radiologic study. Cancer 1983; 52: 1810–1819.

    Google Scholar 

  12. Feig SA, Shaber GA, Patchefskly A. Analysis of clinically occult and mammographically occult breast tumors. AJR 1977; 128: 403–408.

    Google Scholar 

  13. Kalisher L. Factors influencing false negative rates in xeromammography. Radiology 1979; 133: 297–301.

    Google Scholar 

  14. Bekerman C, Hoffer PB, Bitran JD. The role of gallium-67 in the clinical evaluation of cancer. Semin Nucl Med 1984; 14: 296–323.

    Google Scholar 

  15. Larson SM. Mechanism of localization of gallium-67 in tumors. Semin Nucl Med 1978; 8: 193–203.

    Google Scholar 

  16. Hisada K, Tonami N, Miyamae T, et al. Clinical evaluation of tumor imaging with T1–201 chloride. Radiology 1978; 129: 497–500.

    Google Scholar 

  17. Sahweil AM, Mckillop JH, Milroy R, Wilson R, AbdelDayem HM, Omar YT. Mechanism of Tl-201 uptake in tumors. Eur J Nucl Med 1989; 15: 376–379.

    Google Scholar 

  18. Sahweil AM, Mckillop JH, Milroy R, et al. Thallium-201 scintigraphy in the staging of lung cancer, breast cancer and lymphoma. Nucl Med Commun 1990; 11: 263–269.

    Google Scholar 

  19. Waxman AD, Ramanna L, Memsic LD, et al. Thallium scintigraphy in the evaluation of mass abnormalities of the breast. J Nucl Med 1993; 34: 18–23.

    Google Scholar 

  20. Aktolun C, Bayhan H, Kir M, et al. Clinical experience with Tc-99m MIBI imaging in patients with malignant tumors: preliminary results and comparison with TI-201. Clin Nucl Med 1992; 17: 171–176.

    Google Scholar 

  21. Hassan IM, Sahweil A, Constantinides C, et al. Uptake and kinetics of Tc-99m hexakis 2-methoxy isobutyl isonitrile in benign and malignant lesions in the lungs. Clin Nucl Med 1989; 14: 333–340.

    Google Scholar 

  22. O'Driscoll CM, Baker F, Casey MJ, Duffy GJ. Localization of recurrent medullary thyroid carcinomas with technetium-99m-methoxyisobutylnitrile scintigraphy: a case report. J Nucl Med 1991; 32: 2281–2283.

    Google Scholar 

  23. Mueller SP, Piotrowski B, Guth-Tougelides B, Reiners C. Tc-99m MIBI and Tl-201 uptake in thyroid carcinoma. [abstract]. J Nucl Med 1988; 29: 854.

    Google Scholar 

  24. O'Tuama LA, Packard AB, Treves ST. SPECT imaging of pedriatric brain tumor with hexakis (methyoxyisobutylisonitrile) technetium (I). J Nucl Med 1990; 31: 2040–2041.

    Google Scholar 

  25. Caner B, Kitapci M, Unlu M, et al. Technetium-99m-MIBI uptake in benign and malignant bone lesions: a comparative study with technetuium-99m-MDP. J Nucl Med 1992; 33: 319–324.

    Google Scholar 

  26. Caner B, Kitapci M, Aras T, Erbengi G, Ugur O, Bekdik C. Increased accumulation hexakis (2-methoxyisobutylisonitrile) technetium (I) in osteosarcoma and its metastatic lymph nodes. J Nucl Med 1991; 32: 1977–1978.

    Google Scholar 

  27. Chiu ML, Kronauge JF, Piwnica-Worms D. Effect of mitochondrial and plasma membrane potentials on accumulation of hexakis (2-methoxyisobutylisonitrile) technetium (I) in cultured mouse fibroblast. J Nucl Med 1990; 31: 1646–1653.

    Google Scholar 

  28. Piwnica-Worms D, Holman BL. Noncardiac applications of hexakis (alkylsionitrile) technetium-99m complexes. J Nucl Med 1990; 31: 1166–1167.

    Google Scholar 

  29. Savi A, Gerundini P, Zoli P, et al. Biodistribution of Tc-99m methoxy-isobutyl-isonitrile (MIBI) in humans. Eur J Nucl Med 1989; 15: 597–600.

    Google Scholar 

  30. Campeau RJ, Kronemer KA, Sutherland CM. Concordant uptake of Tc-99m sestamibi and Tl-201 in unsuspected breast tumor. Clin Nucl Med 1992; 17: 936–937.

    Google Scholar 

  31. Khalkhali 1, Mena I, Jouanne E, Diggles L, Alle K, Klein S. Tc-99m-sesta MIBI prone breast imaging in patients with suspicion of breast cancer [abstract]. J Nucl Med 1993;34(Supp15):140P.

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Correspondence to: C.H. Kao

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Kao, C., Wang, S. & Liu, T. The use of technetium-99m methoxyisobutylisonitrile breast scintigraphy to evaluate palpable breast masses. Eur J Nucl Med 21, 432–436 (1994). https://doi.org/10.1007/BF00171419

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  • DOI: https://doi.org/10.1007/BF00171419

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