Abstract
Inflammatory pseudotumor (IPT) of the liver is a rare entity often mistaken for malignancy. All children reported to date have been diagnosed and treated surgically, whereas successful medical diagnosis and treatment has been reported in adults. In this report, we describe the 13th child presenting with IPT of the liver and review the literature to determine diagnostic means to avoid unnecessary surgery. There are no specific presumptive clinical and laboratory findings, including tumor markers and imaging techniques, that distinguish IPT from other space-occupying liver lesions. The negativity of malignant liver tumor markers and hepatitis antigens and normal liver, renal, and other systems are supportive of IPT. The most important diagnostic aid is to bear this entity in mind when a child presents with an unexplained liver mass. Fine-needle aspiration is the most helpful measure to confirm the diagnosis. Surgery should be avoided in the absence of life-threatening complications.
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References
Anthony PP, Telensinghe PU (1986) Inflammatory pseudotumor of the liver. J Clin Pathol 39: 761–768
Bahadori M, Liebow AA (1973) Plasma cell granulomas of the lung. Cancer 31: 191–208
Chen KTK (1984) Inflammatory pseudotumor of the liver. Human Pathol 15: 694–696
Daimaru U, Tuneyoshi M, Enjoji M (1983) Inflammatory pseudotumor. Pediatr Oncol 19: 241–242
Facchetti F, De Wolf Peeters C, De Wever I, Frizzera G (1990) Inflammatory pseudotumor of lymph nodes. Immunohisto-chemical evidence for its fibrohistiocytic nature. Am J Pathol 137: 281–289
Gollapudi P, Chejfee G, Zarling JE (1992) Spontaneous regression of hepatic pseudotumor. Am J Gastroenterol 87: 214–217
Göĝüş S, Büyükpamukçu N (1986) Plasma cell granuloma of the cardio-esophageal region. Turk J Pediatr 28: 255–258
Haith EE, Kepes JJ, Holder TM (1964) Inflammatory pseudotumor involving the common bile duct of a six-year old boy: successful pancreatico-duodenectomy. Surgery 56: 436–441
Hata Y, Sasaki F, Matuoka S, Hamada H, Taguchi K, Hasumi T, Manabe K, Uchino J, Nojima T, Hujioka Y, Inoue K, Morita Y (1992) Inflammatory pseudotumor of the liver in children: report of cases and review of the literature. J Pediatr Surg 27: 1549–1552
Heneghan MA, Kaplan CG, Priebe CJ, Partin J, Partin JS (1984) Inflammatory pseudotumor of the liver: a rare cause of obstructive jaundice and portal hypertension in a child. Pediatr Radiol 14: 433–435
Hertzer NR, Hawk WA, Hermann RE (1971) Inflammatory lesions of the liver which simulate tumor: report of two cases in children. Surgery 69: 839–846
Horiuchi R, Uchida T, Kojima T, Shikata T (1990) Inflammatory pseudotumor of the liver. Cancer 65: 1583–1590
Isobe H, Nishi Y, Fukutomi T, Iwamoto H, Nakamuta M, Sakai H, Andoh B, Sakamoto S, Nawata H (1991) Inflammatory pseudotumor of the liver associated with acute myelomonocytic leukemia. Am J Gastroenterol 86: 238–240
Kaneko T, Mitarzi Y, Watasugi K (1984) A case of inflammatory pseudotumor of the liver. Jap Soc Pediatr Surg 20: 167–171
Lupovitch A, Chen R, Mishra S (1989) Inflammatory pseudotumor of the liver. Report of the fine needle aspiration cytologic findings in a case initially misdiagnosed as malignant. Acta Cytol 33: 259–262
Newbould MJ, Kelsey A, Lendon M, Gururangan S (1992) Inflammatory pseudotumor of the liver masquerading as a metastasis in a child treated for neuroblastoma. Med Pediatr Oncol 20: 172–175
Pack GT, Baker HW (1953) Total right hepatic lobectomy. Report of a case. Ann Surg 138: 253–258
Shek TWH, Ng IOL, Chan KW (1993) Inflammatory pseudotumor of the liver. Report of four cases and review of the literature. Am J Surg Pathol 17: 231–238
Shinada K, Uchino T, Taira T (1980) A case of inflammatory pseudotumor of the liver. Pediatr Oncol 15: 26–29
Soares J, Nunes JF, Sacadura J (1987) Plasma cell granuloma of the tongue. Report of a case. Histol-Histopathol 2: 199–201
Someren A (1978) “Inflammatory pseudotumor” of liver with occlusive phlebitis. Am J Clin Pathol 69: 176–181
Standiford SB, Sobel H, Dasmahapatra KS (1989) Inflammatory pseudotumor of the liver. J Surg Oncol 40: 283–287
Tanyel FC, Çakmak O, Akman E (1987) Plasma cell granuloma (inflammatory pseudotumor): a hitherto unreported complication of appendicitis during childhood. Pediatr Surg Int 2: 317–318
West SG, Pittman DL, Coggin JT (1980) Intracranial plasma cell granuloma. Cancer 46: 330–335
Wiernik PH, Rader M, Becker NH, Morris SF (1990) Inflammatory pseudotumor of spleen. Cancer 66: 597–600
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Ciftci, A.O., Çaĝlar, M., Tanyel, F.C. et al. Diagnostic aids in inflammatory pseudotumor of the liver. Pediatr Surg Int 10, 161–164 (1995). https://doi.org/10.1007/BF00171183
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DOI: https://doi.org/10.1007/BF00171183