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Rapid measurement of blood leakage during regional chemotherapy

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Abstract

In order to avoid complications after regional chemotherapy (isolated hyperthermic perfusion) of the extremities, rapid measurement of blood leakage from the extracorporeal to the systemic circulation is important. A method using technetium-99m in vivo red blood cell (RBC) labelling is reported that provides results within 3 min. Blood samples drawn from the systemic and the extracorporeal circulation were measured for 99mTc activity using a mobile well counter, and the leakage values calculated. The mean result was 7.6%±6.5%/15 min (n=209). The corresponding flow rate was 100.2±85.7 ml/15 min (mean ± SD). The values for isolation perfusion of the upper and the lower extremities are compared. The leakage results using 99mTc RBC labelling were correlated with other blood pool markers. Iodine-125 human serum albumin and indium-113 m transferrin were administered in subgroups of 4 and 19 patients simultaneously. Using linear regression, the coefficient of correlation was 0.72 for 99mTc/113mIn and 0.58 for 99mTc/125I. Comparison with the alternatives suggests that the rapid method of leakage measurement after 99mTc RBC labelling can be considered one of the most practicable and reliable methods available.

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Authors and Affiliations

  1. Department of Nuclear Medicine, Saarland University Medical School, Oscar-Orth-Strasse, W-6650, Homburg, Germany

    Christof Alexander

  2. Department of General Surgery, Saarland University Medical School, Oscar-Orth-Strasse, W-6650, Homburg, Germany

    Georg Omlor, Georg Grosse & Gernot Feife1

  3. Department of Nuclear Medicine, City Hospital Wuppertal, Heusnerstrasse 40, W-5600, Wuppertal 2, Germany

    Richard Berberich

Authors
  1. Christof Alexander
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  2. Georg Omlor
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  3. Richard Berberich
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  4. Georg Grosse
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  5. Gernot Feife1
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Additional information

This paper is dedicated to Prof. E. Oberhausen, Homburg/Saar, on the occasion of his 65th birthday

Correspondence to: C. Alexander

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Alexander, C., Omlor, G., Berberich, R. et al. Rapid measurement of blood leakage during regional chemotherapy. Eur J Nucl Med 20, 187–191 (1993). https://doi.org/10.1007/BF00169996

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  • DOI: https://doi.org/10.1007/BF00169996

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