Summary
α-Fluoromethylhistidine (α-FMH; 65 mg/kg, i.p.), a specific inhibitor of histidine decarboxylase, significantly decreased the histamine content of the rat right atrium in a time-dependent manner; the maximal decrease of 22.2% was observed 4 h after injection. However, α-FMH had no significant effect on the histamine content of the left atrium or the ventricles. The α-FMH-induced decrease in the right atrial histamine content was not observed in rats pretreated with 6-hydroxydopamine (25 mg/kg, i.p.). Two i.p. injections of 10 and 5 mg/kg of propranolol and the cardioselective β1-adrenoceptor antagonist metoprolol almost completely inhibited the α-FMH-induced histamine decrease. On the other hand, phentolamine (10 mg/kg, i.p.) had no influence on the histamine-decreasing action of α-FMH. These results suggest that in the rat right atrium there is a histamine pool where a rapid turnover of histamine is maintained by normal sympathetic activity.
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References
Assem ESK, Ghanem NS, Azizan Abdullah N (1987) Comparison of the response of mast cells in guinea-pig cardiac atria and ventricles. Agents Actions 20:1–9
Boucher M, Jung MJ, Gerhart F (1983) Effect of prolonged inhibition of histidine decarboxylase on tissue histamine concentration. Experientia 39:1303 -1305
Broadley KJ, Wilson C, Smith IR, Owen DAA (1980) Uptake and metabolism of histamine in guinea-pig isolated atria and their relationship to the pharmacological responses. Naunyn-Schmiedeberg's Arch Pharmacol 315:155–161
Brogden RN, Heel RC, Speight TM, Avery GS (1977) Metoprolol; a review of its pharmacological properties and therapeutic efficacy in hypertension. Drugs 14:321–348
Corrodi H, Masuoka DT, Clark WG (1971) Effect of 6-hydroxydopamine on rat heart noradrenaline. Eur J Pharmacol 15: 160–163
Garbarg M, Barbin G, Rodergas E, Schwartz JC (1980) Inhibition of histamine synthesis in brain by α-fluoromethylhistidine, a new irreversible inhibitor; in vitro and in vivo studies. J Neurochem 35:1045–1052
Giotti A, Guidotti A, Mannaioni PF, Zilletti L (1966) The influence of adrenotropic drugs and noradrenaline on the histamine release in cardiac anaphylaxis in vitro. J Physiol (Lond) 184:924–941
Gross SS, Guo ZG, Levi R, Bailey WH, Chenouda AA (1984) Release of histamine by sympathetic nerve stimulation in the guinea-pig heart and modulation of adrenergic responses: A physiological role for cardiac histamine? Circ Res 54:516–526
Gross SS, Levi R (1985) Histamine modulation of cardiac sympathetic responses. In: Ganellin CR, Schwartz JC (eds) Frontiers in histamine research, Advances in tile biosciences, vol 51. Pergamon, Oxford, pp 317–324
Johnson HL (1969) Non mast-cell histamine kinetics. II. Effect of histidine decarboxylase inhibitors on rates of decline of tissue 3H-histamine in the female rat. Biochem Pharmacol 18:651–658
Johnson HL (1970) Non mast-cell histamine kinetics. III. Uptake, metabolism and decline of 3H-histamine in the female rat and effects of endogenous histamine release. J Pharmacol Exp Ther 171:88–97
Kimura T, Satoh S (1983) Inhibition of cardiac sympathetic, neurotransmission by histamine in the dog mediated by H1-receptors. Br J Pharmacol 78:733–738
Kollonitsch J, Patchett AA, Marburg S, Maycock AL, Perkins LM, Doldouras GA, Duggan DE, Aster SD (1978) Selective, inhibitors of biosynthesis of aminergic neurotransmitters. Nature (Lond) 274:906–908
Koyama S, Oishi R, Senoh S, Saeki K (1986) Drug-induced changes in histamine and tele-methylhistamine levels in mouse peripheral tissues. Jpn J Pharmacol 40:527–532
Levi R, Gershon MD (1970) Chemical sympathectomy and cardiac action of histamine. Fed Proc 29:612 Abst
Levi R, Guo Z-G (1982) Roles of histamine in cardiac dysfunction. In: Tasaka K, Uvnäs B (eds) Advances in histamine research, Advances in the biosciences, vol 33. Pergamon, Oxford, pp 213–222
Levi R, Owen DAA, Trzeciakowski J (1982) Actions of histamine on the heart and vasculature. In: Ganellin CR, Parsons ME (eds) Pharmacology of histamine receptors. Wright PSG, Bristol; pp 236–297
Levine RJ, Sato TL, Sjoerdsma A (1965) Inhibition of histamine synthesis in the rat by α-hydrazinoanalog of histidine and 4-bromo-3-hydroxy benzyloxyamine. Biochem Pharmacol 14:139–149
Lokhandwala MF (1978) Inhibition of sympathetic nervous system by histamine; studies with H1- and H2-receptor antagonists. J Pharmacol Exp Ther 206:115–122
Maeyama K, Watanabe T, Taguchi Y, Yamatodani A, Wada H (1982) Effect of α-fluoromethylhistidine, a suicide inhibitor of histidine decarboxylase, on histamine levels in mouse tissue. Biochem Pharmacol 31:2367–2370
Mannaioni PF, Moroni F (1973) Uptake, disposition and metabolism of histamine in isolated heart preparations. Br J Pharmacol 49:457–465
Oishi R, Itoh Y, Nishibori M, Saeki K (1985) Δ9-Tetrahydro-cannabinol decreases turnover of brain histamine. J Pharmacol Exp Ther 232:513–518
Oishi R, Mishima S, Kuriyama H (1983) Determination of norepinephrine and its metabolites released from rat vas deferens using high-performance liquid chromatography with electrochemical detection. Life Sci 32:933–940
Oishi R, Nishibori M, Saeki K (1984) Regional differences in the turnover of neuronal histamine in the rat brain. Life Sci 34:691–699
Rand MJ, Storey DF, Wong-Dusting HK (1982) Effect of histamine on the resting and stimulation induced release of (3H)-noradrenaline in guinea-pig isolated atria. Br J Pharmacol 75:57–64
Ryan MJ, Brody MJ (1970) Distribution of histamine in the canine autonomic nervous system. J Pharmacol Exp Ther 174:123–132
Shellenberger MK, Gordon JH (1971) A rapid, simplified procedure for simultaneous assay of norepinephrine, dopamine and 5-hydroxytryptamine from discrete brain areas. Anal Biochem 39:356–372
Shore PA, Burkhalter A, Cohn VH (1959) A method for the fluorometric assay of histamine in tissue. J Pharmacol Exp Ther 127:182–186
Taylor KM, Snyder SH (1972) Dynamics of the regulation of histamine levels in mouse brain. J Neurochem 19:341–353
Tranzer JP, Thoenen H (1968) An electronmicroscopic study of selective acute degeneration of sympathetic nerve terminals after administration of 6-hydroxydopamine. Experientia (Basel) 24:155–156
Tsuruta Y, Kohashi K, Ohkura Y (1981) Simultaneous determination of histamine and Nτ-methylhistamine in human urine and rat brain by high-performance liquid chromatography with fluorescence detection. J Chromatogr 224:105–110
Wolff AA, Levi R (1986) Histamine and cardiac arrhythmias. Circ Res 58:1–16
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Yoshitomi, I., Oishi, R., Itoh, Y. et al. α-Fluoromethylhistidine decreases the histamine content of the rat right atrium under the influence of sympathetic activity. Naunyn-Schmiedeberg's Arch Pharmacol 339, 528–532 (1989). https://doi.org/10.1007/BF00167256
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DOI: https://doi.org/10.1007/BF00167256