Abstract
Pattern electroretrinography (PERG) was performed in 33 patients with chronic open-angle glaucoma (COAG), 18 ocular hypertensive (OH) patients, and 24 normal subjects. COAG patients exhibited significantly lower PERG amplitudes than did normal subjects (P 8rps = 0.025; P 16rps < 0.0001). The OH patients fell into two distinct groups: those with normal PERG scores and those with lower than normal scores. OH patients with PERG scores significantly lower than control values demonstrated significantly larger cup-to-disc ratios (P=0.002) and higher initial intraocular pressures (IOPs) than did OH patients with normal PERG scores (P=0.021). In the 11 OH patients in whom spectral sensitivity measurement was available, statistically significant correlations were found between the blue-cone sensitivity loss and the PERG amplitude (r 8rps )=0.772, P 8rps =0.0053 and r 16rps =0699, P 16rps =0.0167, respectively. our results demonstrate reduced PERG amplitude in high-risk OH patients and further illustrate the correlation between PERG amplitude and blue-cone spectral sensitivity in OH subjects. Confirmation of the roles of PERG and spectral sensitivity in the detection of early glaucoma requires longitudinal study.
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Bielik, M., Zwas, F., Shin, D.H. et al. PERG and spectral sensitivity in ocular hypertensive and chronic open-angle glaucoma patients. Graefe's Arch Clin Exp Ophthalmol 229, 401–405 (1991). https://doi.org/10.1007/BF00166299
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DOI: https://doi.org/10.1007/BF00166299