Abstract
Clinical observation of eight patients with superficial stromal precipitation of calcium phosphate is presented. In all cases the predisposing factors for the formation of these depositions were: epithelial defects and the combined use of topical dexamethason phosphate or prednisolon phosphate with topical beta-blocking agents. In two patients the medication that gave rise to these precipitates was used without preservatives, suggesting that the medication itself and not the preservatives contribute to the deposits. Discontinuance of simultaneous administration of the steroids and beta-blocking agents prevented further formation of precipitates. The authors suggest an interaction between simultaneously given steroid and betablocking agents, giving rise to calcium phosphate precipitates when an epithelial defect is present which allows easy access to the superficial corneal stroma.
Similar content being viewed by others
References
O'Connor, R. Calcific Band Keratopathy Trans Am. Ophthalmol Soc. 1972; 70: 58–81.
Cogan, D.G., Albright, F., Bartter F.C., Hypercalcemia and Band Keratopathy Arch. Ophthalmol. 1948; 40: 624.
Kennedy, R.E., Roca, D.P., Landers, P.H., Atypical Band Keratopathy in Glaucomatous Patients Am. J. Ophthalmol. 1971; 72: 917–922.
Beekhuis, W.H., Silicone oil keratopathy, Indications for Keratoplasty Br.J. Ophthalmol. 1985; 69: 247–253.
Ullman, S., Lichtenstein S.B., Heerlein, K. Corneal Opacities Secondary to Viscoat J. Cat. Refract. Surg 1986; 12: 489–492.
Nevyas, A.S., Raber, I.M., Eagle, C., Wallace I.B., Nevyas, H.J., Acute Band keratopathy Following Intracameral Viscoat Ach. Ophthalmol. 1987; 105: 958–964.
Freddo, T.F., Leibowitz, H.M., Bilateral Acute Corneal Calcification Ophthalmology 1985; 92: 537–542.
Remeijer, L., Van Rij, G., Mooij, C.M., Beekhuis, W.H., Renardel de Lavalette, J.G.C. Infections Crystalline Keratopathy Doc. Ophthalmol. 1987; 67: 95–103.
Wiesenthal, R.W., Krachner, J.H., Folber, R., Dann, S.P., Whitson W.E., Postkeratoplasty Crystalline Deposits Mimicking Bacterial Infectious Crystalline Keratopathy Am. J. Ophthalmol. 1988; 105: 70–74.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Huige, W.M.M., Beekhuis, W.H., Rijneveld, W.J. et al. Unusual deposits in the superficial corneal stroma following combined use of topical corticosteroid and beta-blocking medication. Doc Ophthalmol 78, 169–175 (1991). https://doi.org/10.1007/BF00165677
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00165677