Abstract
It has been suggested that albinolike misrouting of the visual pathway occurs in patients with dissociated vertical deviation (DVD). We re-examined this contention in ten DVD patients using visually evoked potentials. Full-field monocular pattern-onset checker-board stimulation was employed. The visually evoked potentials were recorded simultaneously from both occipital lobes. Their differential activity during stimulation of the right eye was compared with that obtained during stimulation of the left. We found no predominance of crossed projection in any of the DVD cases. The results in nine normal subjects were similar. In 13 albino patients, however, there was a relative positivity in the contralateral hemisphere about 100 ms after pattern-onset, which reconfirmed predominance of the crossed projection. Possible artifacts are discussed that may have led to the assumption of misrouting in DVD in two previous reports.
Similar content being viewed by others
References
Apkarian P, Reits D, Spekreijse H, Dorp D van (1983) A decisive electrophysiological test for human albinism. Electroencaphalogr Clin Neurophysiol 55:513–531
Bach M (1990) Die Sehbahnfehlprojektion bei Albinismus- eine neue Anwendung evozierter Potentiale in der Ophthalmologic. Orthoptik Pleoptik 15:7–14
Bach M, Kommerell G (1989) Das Überwiegen kreuzender Sehnervenfasern ist em Charakteristikum des Albinismus, aber nicht der dissoziierten Vertikaldeviation. Fortschr Ophthalmol 86:253–255
Bach M, Röver J, Bornscheuer C (1988) Nachweis der SehbahnFehlprojektion bei Albinismus mit visuell evozierten Potentialen. Klin Monatsbl Augenheilkd 192:372
Barret G, Blumhardt L, Halliday AM, Halliday E, Kriss A (1976) A paradox in the lateralisation of the visual evoked response. Nature 261:253–255
Boylan C, Clement RA, Howrie A (1988) Normal visual pathway routing in dissociated vertical deviation. Invest Ophthalmol Vis Sci 29:1165–1167
Brindley GS (1982) The variability of the human striate cortex. J Physiol 225:1–3
Creel D, Spekreijse H, Reits D (1981) Visual evoked potential (VEP) methods of detecting misrouted optic projections. Doc Opthamol Proc Ser 27:157–165
Fitzgerald A (1983) Evidence of abnormal optic nerve fibre projections in patients with dissociated vertical deviation (DVD) — a preliminary report. Aust Orthoptic J 20:23–29
Fitzgerald BA, Billson FA (1984) Dissociated vertical deviation: evidence of abnormal visual pathway projection. Br J Ophthalmol 68:801–806
Guillery RW (1990) Normal and abnormal visual field maps in albinos. Central effects of non-matching maps. Ophthalmic Paediatr Genet 11:177–183
Kinnear PE, Barrie J, Witkop CJ (1985) Albinism. Surv Ophthalmol 30:5–101
Kommerell G, Mattheus S (1984) Reversed fixation test (RFT), a new tool for the diagnosis of dissociated vertical deviation (DVD). In: Reinecke RD (ed) Strabismus II. Grime & Stratton, Orlando, pp 721–728
Kriss A, Timms C, Elston J, Taylor D (1988) Pattern- and flash-evoked potentials in patients with dissociated vertical deviation. Doe Ophthalmol 69:283–291
Kriss A, Timms C, Elston J, Taylor D, Gresty M (1989) Visual evoked potentials in dissociated vertical deviation: a reappraisal. Br J Ophthalmol 73:265–270
Silver J, Sapiro J (1981) Axonal guidance during development of the optic nerve: the role of pigmented epithelia and otherintrinsic factors. J Comp Neurol 202:521–538
Stensaas SS, Eddington DK, Dobelle WH (1974) The topography and variability of the primary visual cortex in man. J Neurosurg 40:747–755
Webster MJ, Shatz CJ, Kliot M, Silver J (1988) Abnormal pigmentation and unusual morphogenesis of the optic stalk may be correlated with retinal axon misguidance in embryonic Siamese cats. J Comp Neurol 269:592–611
Author information
Authors and Affiliations
Additional information
Offprint requests to: M. Bach
Rights and permissions
About this article
Cite this article
Bach, M., Kommerell, G. Albino-type misrouting of the optic nerve fibers not found in dissociated vertical deviation. Graefe's Arch Clin Exp Ophthalmol 230, 158–161 (1992). https://doi.org/10.1007/BF00164655
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00164655