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Toxicity effects of alcohols on Saccharomyces cerevisiae: A flow microcalorimetry investigation

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Biotechnology Techniques

Summary

The 50% inhibitory concentrations (IC50) of n-alcohols (C2, n-C3 to n-C7) were found well correlated with n-alcohols partition coefficients showing a relationship between toxicity and hydrophobicity. The inhibitory behavior of ethanol was examined through systematic variations of glucose and alcohol concentrations; the results show non-competitive inhibition of glucose metabolism for low ethanol concentration (0–12% v/v).

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Authors and Affiliations

  1. Département de biologie, Université de Sherbrooke, J1K 2R1, Sherbrooke, Québec, Canada

    G. Viel & P. Béchard

  2. Département de chimie, Université de Sherbrooke, J1K 2R1, Sherbrooke, Québec, Canada

    C. Jolicoeur & A. Beaubien

Authors
  1. G. Viel
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  2. P. Béchard
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  3. C. Jolicoeur
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  4. A. Beaubien
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Viel, G., Béchard, P., Jolicoeur, C. et al. Toxicity effects of alcohols on Saccharomyces cerevisiae: A flow microcalorimetry investigation. Biotechnol Tech 1, 73–78 (1987). https://doi.org/10.1007/BF00159325

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  • DOI: https://doi.org/10.1007/BF00159325

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