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Double kinetic resolution of (±) ethyl 4 - chloro - 3- 0-acetyl butanoate

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Summary

Single pot double kinetic resolution of (±) ethyl 4-chloro-3-O-acetyl butanoate 1 by transesterification with n-butanol in diisopropyl ether using the enzyme Candida Cylindracea Lipase (CCL) is investigated. This technique is found to give products with better optical purity.

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Authors and Affiliations

  1. Chemistry Division, The Institute of science, 15, Madam Cama Road, 400 032, Bombay, India

    Narendra V. Thakkar

  2. Alchemie Research Centre, Thane Belapur Road, P.B. No.155, 400601, Thana, India

    Hanumanthsa S. Bevinakatti

Authors
  1. Narendra V. Thakkar
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  2. Ankur A. Banerji
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  3. Hanumanthsa S. Bevinakatti
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Thakkar, N.V., Banerji, A.A. & Bevinakatti, H.S. Double kinetic resolution of (±) ethyl 4 - chloro - 3- 0-acetyl butanoate. Biotechnol Lett 16, 1299–1302 (1994). https://doi.org/10.1007/BF00149635

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  • DOI: https://doi.org/10.1007/BF00149635

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