Summary
A mutant of S. aureofaciens characterized by lower growth and higher tetracycline production than its parent strain is described. The mutant has a limited degree of temperature-sensitivity and shows a lower efficiency in the utilization of phosphate for growth and a higher cellular content of RNA. The data are in accordance with a possible mutation impairing some aminoacyl RNA synthetases. This kind of mutation might explain the lower growth in phosphate limited conditions and the higher content of RNA.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Atherly, A.G. (1974) Cell.3, 145–151
Beremblum, I. and Chain, E. (1938) Biochem. J.32, 295–298
Drew, S.A. and Demain, A.L. (1977) Ann. Rev. Microbiol.31, 343–356
Eidlic, L. and Neidhardt, F.C. (1965) J. Bacteriol.89, 706–711
Makarevich, U.G., Upiter, G.D., Slugina, M.D., Tarasova, S.S. (1975) Antibiotiki20, 295–299
Martin, R.F. and Donohue, Diana C. (1972) Analyt. Biochem.47, 562–574
Martin, J.F. (1977) In: Advances in Biochemical Engineering, T.K. Ghose, A. Fiechter, N. Blakebrough, eds. vol. 6, pp. 105–127. Springer-Verlag, Berlin, Heidelberg, New York.
Munro, N.N. and Fleck, E. (1966) Analyst.91, 78
Racine, F.M., Steinberg, W. (1974) J. Bacteriol.120, 373–383
Simuth, J., Hudec, J., Chan, H.T., Danyi, O., Zelinka, J. (1979). The Journal of Antibiotics32, 53–58.
Vorisek, J., Powell, A.J. and Vanek, Z. (1969) Folia Microbiol.14, 398–405.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Colombo, A.L., Crespi-Perellino, N., Grein, A. et al. Metabolic and genetic aspects of the relationship between growth and tetracycline production in Streptomyces aureofaciens . Biotechnol Lett 3, 71–76 (1981). https://doi.org/10.1007/BF00145113
Issue Date:
DOI: https://doi.org/10.1007/BF00145113