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Hemodynamic effects of the D- and L-isomers of sotalol on normal myocardium

  • Hemodynamics
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Summary

This study investigated the hemodynamic effects of the D-isomer of sotalol in open-chest rats and compared this to the action of the L-isomer and the racemic DL-sotalol. Hemodynamic and additional isovolumic maximum measurements were registered at the end and 5 minutes after an intravenous infusion period of 7 minutes. DL- (1 and 2 mg/kg) and L-sotalol (2 mg/kg) caused a significant reduction in the heart rate and in the indices of contractility during and after infusion. D-sotalol (2, 4, and 8 mg/kg), however, decreased the contractility only transiently after very high doses at high plasma concentrations. Thus, while the effects of the beta-blocking L-isomer were comparable to those of DL-sotalol, only a slight and transient hemodynamic action of comparable doses of D-sotalol was found. These findings may be of significance for the proposed use of the D-isomer as a class-III antiarrhythmic agent.

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Authors and Affiliations

  1. Medizinische Klinik, Abt. III, Universität Tübingen, Tübingen, Germany

    Hans Martin Hoffmeister, Martin Beyer & Ludger Seipel

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  1. Hans Martin Hoffmeister
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  2. Martin Beyer
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  3. Ludger Seipel
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Hoffmeister, H.M., Beyer, M. & Seipel, L. Hemodynamic effects of the D- and L-isomers of sotalol on normal myocardium. Cardiovasc Drug Ther 5, 1027–1033 (1991). https://doi.org/10.1007/BF00143531

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