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Mechanism of resistance to streptothricin of a producing microorganism

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Summary

Streptothricin antibiotics are potent inhibitors of bacterial protein synthesis. Although a streptothricin-producing microorganism is tolerant to its own products in vivo, the ribosomes are sensitive to the action of the antibiotic in vitro. However, the organism possesses a novel streptothricin-inactivating enzyme (streptothricin-acetyltransferase) which may contribute to protection of protein synthesis against the endogenous product.

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Authors and Affiliations

  1. Department of Fermentation Technology, Faculty of Engineering Hiroshima University Saijo-cho, 724, Higashi-Hiroshima, Japan

    S. Keeratipibul, M. Sugiyama & R. Nomi

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  1. S. Keeratipibul
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  2. M. Sugiyama
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  3. R. Nomi
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Keeratipibul, S., Sugiyama, M. & Nomi, R. Mechanism of resistance to streptothricin of a producing microorganism. Biotechnol Lett 5, 441–446 (1983). https://doi.org/10.1007/BF00132225

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