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Receptors and transduction mechanisms in anterior pituitary: Primary cultures, transfected clonal cells and human tumor derived cells

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Conclusion

In conclusion anterior pituitary cells represent a very good model for the study of receptors andtransduction mechanisms. Each cellular model has its limitation, heterogeneity, non-physiological regulation, and species specificity. However, combination of approaches givesinteresting information, useful to understand not only the physiological regulation of hormonesecretion, but also pathological situations. Since receptors present in the pituitary are alsolocated in other tissues, including the brain, the digestive tract, and the lymphocytes, theinformation can also be extended to many other functions. In fact, a given receptor seems tobe always associated with the same coupling mechanism in all target tissues. In contrast,receptor and G protein concentrations, coupling efficiency and cross talk betwen transductionprocesses appear specific of a given cell type. These parameters are thus likely to play animportant role in the specificity of cellular responses.

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  1. Unité 159 INSERM, Paris, France

    Alain Enjalbert

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Enjalbert, A. Receptors and transduction mechanisms in anterior pituitary: Primary cultures, transfected clonal cells and human tumor derived cells. Cell Biol Toxicol 8, 19–28 (1992). https://doi.org/10.1007/BF00130507

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