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A tandem enzymatic hydrolysis of 3-acetylthio-2-methylpropionic methy ester

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Summary

Enzymatic hydrolysis of racemic 3-acetylthio-2-methylpropionic methyl ester catalyzed by bovine pancreatic protease and Mucor javanicus lipase showed opposite enantioselecivity. A tandem hydrolysis of the ester catalyzed by these two enzymes gives enantiomerically enriched (S)-3-acetylthio-2-methylpropionic acid, a building block of captopril.

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Authors and Affiliations

  1. Biochemical Engineering Center, Da-Yen Institute of Technology, Chang-Hwa, Taiwan, R.O.C.

    Dar-Fu Tai, Ching-Chong Huang, Hui-Yao Huang & Ing-Lung Shih

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  1. Dar-Fu Tai
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  2. Ching-Chong Huang
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  3. Hui-Yao Huang
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  4. Ing-Lung Shih
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Tai, DF., Huang, CC., Huang, HY. et al. A tandem enzymatic hydrolysis of 3-acetylthio-2-methylpropionic methy ester. Biotechnol Lett 15, 1229–1232 (1993). https://doi.org/10.1007/BF00130302

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