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Baeyer-Villiger monooxygenase-dependent biotransformations: Stereospecific heteroatom oxidations by camphor-grown Pseudomonas putida to produce chiral sulfoxides

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Summary

Camphor-grown Pseudomonas putida NCIMB 10007 catalysed the stereospecific oxygenation of various alkyl aryl sulfides to equivalent S-(\s-)-sulfoxides. The structure of the sulfide significantly influenced both the yield and the optical purity of the predominant product. The biotransformations were catalysed exclusively by the Baeyer-Villiger monooxygenases present in camphor-grown P. putida.

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Authors and Affiliations

  1. Departments of Biological Sciences, Exeter University, EX4 4QG, Exeter, Devon, Gt. Britain

    Jean Beecher & Andrew Willetts

  2. Chemistry, Exeter University, EX4 4QG, Exeter, Devon, Gt. Britain

    Paul Richardson

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  1. Jean Beecher
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  2. Paul Richardson
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  3. Andrew Willetts
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Beecher, J., Richardson, P. & Willetts, A. Baeyer-Villiger monooxygenase-dependent biotransformations: Stereospecific heteroatom oxidations by camphor-grown Pseudomonas putida to produce chiral sulfoxides. Biotechnol Lett 16, 909–912 (1994). https://doi.org/10.1007/BF00128623

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