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Inhibition of gap-junctional intercellular communication between Chinese hamster lung fibroblasts by di(2-ethylhexyl) phthalate (DEHP) and trisodium nitrilotriacetate monohydrate (NTA)

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Abstract

Di(2-ethylhexyl)phthalate and trisodium nitrilotriacetate monohydrate, two apparently nongenotoxic carcinogens, were tested for effects on gap-junctional communication between Chinese hamster V79 lung fibroblasts. Both compounds inhibited gap-junctional communication in a concentration-dependent manner. The inhibiting effects of these chemicals on gap-junctional communication in vitro correlate with their tumor-promoting activity. Such results further support the hypothesis that inhibition of gap-junctional communication is an in vitro biomarker for some tumor-promoting chemicals.

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Abbreviations

CAS:

Chemical Abstracts Service

DEHP:

di(2-ethylhexyl)phthalate

GJIC:

gap-junctional intercellular communication

NTA:

trisodium nitrilotriacetate monohydrate

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Authors and Affiliations

  1. Environmental Research Laboratory, U.S. EPA, Narragansett, Rhode Island

    A. Russell Malcolm

  2. Science Applications International Corporation, Narragansett, Rhode Island

    Lesley J. Mills

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Malcolm, A.R., Mills, L.J. Inhibition of gap-junctional intercellular communication between Chinese hamster lung fibroblasts by di(2-ethylhexyl) phthalate (DEHP) and trisodium nitrilotriacetate monohydrate (NTA). Cell Biol Toxicol 5, 145–153 (1989). https://doi.org/10.1007/BF00122649

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