Summary
Long term observations of the gene pool of the same and geographically separated populations of Drosophila melanogaster forced us to return to the old idea of De Vries about the existence of mutation periods and fluctuations in the mutation rate with time. A 3- to 5-fold increase of the total mutation rate was estimated by the frequency of lethals, and outbursts of mutability of some X-linked loci were registered. In 1973 the mutation frequency of the singed bristle locus increased in many populations. An outburst of mutability up to 10-2 – 10-3 was accompanied by the unstable conditions of newly arisen mutations, and their ability to produce with a great frequency various allelic variants in the progeny.
Two main types of instability have been established: (A) Changes occur in accordance with the ‘all or nothing’ principle: from an extreme mutant expression to a phenotypically normal one, and vice versa; (B.) Mutants with intermediate phenotypic expression give rise to a fan of allelic derivatives in progeny. Mutations occur long before meiosis and proceed at different rates in sexual and somatic cells. The whole body of indirect evidence indicates that the instability is the result of the incorporation of insertion mutations and frequent changes of orientation of some alien segments of DNA.
When evaluating the mutation process in natural populations one should take into account that:
-
(1)
mutation rate is not a constant value and in nature undergoes considerable time fluctuations;
-
(2)
synchronous changes of mutability both total and at specific loci are observed;
-
(3)
long term studies show the existence of ‘mutation fashions’. With time one fashion changes to other;
-
(4)
insertional mutations constitute an essential component of the spontaneous mutation process.
It is suggested that some infectious agents may be acting synchronously in isolated populations as selective factor and as factor inducing unstable states of genetic loci.
Similar content being viewed by others
References
Anderson, W., Th. Dobzhansky, O. Pavlovsky, I. Powell & D. Yardley. (1975) Genetics of natural populations. XLII Three decades of genetic change in Drosophila pseudo-obscura. Evolution 29: 24–36.
Berg, R.L. (1966). Studies of mutability in geographically isolated populations of Drosophila melanogaster. In: Mutation in population. Ed. R. Hončariv. Prague, Chechosl. Acad. Sci. 61–74.
Berg, R.L. (1972). A sudden and synchronous increase in the frequency of abnormal abdomen in the geographically isolated populations of Drosophila melanogaster. Drosophila Inf. Serv. 48: 94.
Berg, R.L. (1973). A further study of the rate of ‘abnormal abdomen’ (aa) in geographically isolated D. melanogaster populations. Drosoph. Inf. Serv. 50, 92.
Berg, R.L. (1974). A simultaneous mutable raise at the singed locus in two out three Drosophila melanogaster population studied in 1973. Drosophila Inf. Serv. 51, 100.
Campbell, A. (1974). Episomes. In: ‘Handbook of Genetics’, ed. R.C. King, No 4: 295–309. Plenum Press, New York.
Carson, H.L. (1975). The genetics of speciation at the diploid level. Amer. Nat. 109: 83–92.
Cohen, S. (1976). Transposable genetic elements and plasmid evolution. Nature 263: 731–736.
Demerec, M. (1927). The behaviour of mutable genes. Proc. V int. Conf. Genet.: 183–193.
Dobzhansky, Th. (1971). Evolutionary oscillations in Drosophila pseudo-obscura. In: Ecological Genetics and Evolution, (Essays in honour of E.B. Ford). R. Creed, ed. Black-well, Oxford-Edinburgh: 109–120.
Duseeva, N.D. (1948). High mutability ‘yellow’ gene in populations of Drosophila melanogaster. Dokl. Acad. Sci. USSR 59: 329–332. (In Russian).
Fineham, I.R.S. (1973). Localised instabilities in plants — a review and some speculation. Genetics, 73: 195–206.
Gateff, E., M.D. Golubovsky & K.S. Sokolova (1977). Lethal phase, morphology and developmental capacities of the presumptive adult optic centers in the larval brain and the imaginal dises of fifteen 1(2)gl alleles and a net 1(2)gl deficieney. Drosoph. Inf. Serv. 52: 128.
Gershenson, S.M. (1941). New data on genetics of natural populations of D. melanogaster. ‘Memoirs of Genetics’, No 4–5: 13–39. Papers Inst. Zool. Acad. Sci. Ukr SSR (In Ukrainian).
Gershenson, S.M., Y.N. Alexandrov & S.S. Maliuta (1971). Production of recessive lethals in Drosophila by viruses non-infections for the host. Mutat. Res. 11: 163–173.
Gershenson, S.M., Y.N. Alexandrov & S.S. Maliuta (1975). Mutagenic action of DNA and viruses in Drosophila. Naukova Dumka, Kiev.
Gilbert, W. (1978). Why genes in pieces? Nature 271: 501.
Golubovsky, M.D. (1977a). Instability of singed locus in Drosophila melanogaster: phenotypically mutant and normal alleles mutating in accordance with rule ‘all or gone’. Genetika (Moscow) 13: 847–861 (In Russian).
Golubovsky, M.D. (1977b). Unstable allele of singed locus in Drosophila melanogaster and its derivatives mutating in different directions. Genetika (Moscow) 13: 1030–1041 (In Russian).
Golubovsky, M.D. (1978). Unstable lozenge and ‘fine bristle’ mutations from Far East population. Drosoph. Inf. Serv. 53: 122.
Golubovsky, M.D., I.D. Erokhina (1977). Mutational process in lines with supermutable singed alleles in Drosophila melanogaster. Genetika 13: 1210–1219 (In Russian).
Golubovsky, M.D., Yu.N. Ivanov & M.M. Green (1977). (Genetic instability in Drosophila melanogaster: Putative multiple insertion mutants of the singed bristle locus. Proc. natn. Acad. Sci. U.S.A. 74: 2973–2975.
Golubovsky, M.D., Yu.N. Ivanov, I.K. Zakharov & R.L. Berg (1974). Investigation of synchronous and similar changes of the gene pool in geographically separated natural populations of Drosophila melanogaster. Genetika 10: 72–83 (In Russian).
Golubovsky, M.D. & K.B. Sokolova (1973). The expression and interaction of different alleles at the 1(2)gl locus. Drosoph. Inf. Serv. 50: 124.
Green, M.M. (1969): Controlling element mediated transpositions of the white gene in Drosophila melanogaster. Genetics 61: 429–441.
Green, M.M. (1973). Some observations and comments on mutable and mutator genes in Drosophila. Genetics suppl. 73: 187–194.
Gvozdev, V.A. (1978). Eukaryotic genome organisation. Molec. Biol. (Moscow) 12: 5–35.
Hartl, D.L., & M.M. Green (1970). Genetic studies of germinal mosaicism in Drosophila melanogaster using the mutable wc gene. Genetics 65: 449–455.
Henderson, S.A., R.C. Woodruff & I.N. Thompson (1978). Spontaneous chromosome breakage at male meiosis associated with male recombination in Drosophila melanogaster. Genetics 88: 93–107.
Hexter, W.M. (1955). Functional and spatial pseudoallelism of the singed locus in Drosophila melanogaster. Proc. natn. Acad. Sci. U.S.A. 41: 921–925.
Howe, M.M. & E.G. Bade (1975). Molecular biology of bacteriophage Mu. Science 190: 624–632.
Hozumi, N. & S. Tonegawa (1976). Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions. Proc. natn. Acad. Sci. U.S.A. 73: 3628–3632.
Ising, G. (1976). Genetic and cytology of a small transposition induced by the transposing element TE. V Eur. Drosoph. Conf. Belgium: 6–8.
Ivanov, Yu. N. & M.D. Golubovsky (1977). Increase of mutation rate and appearance of unstable alleles of the singed gene in natural population of Drosophila melanogaster. Genetika (Moscow) 13: 655–665.
Kidwell, M.G., I.F. Kidwell & I.A. Sved (1977). Hybrid dysgenesis in D. melanogaster. A syndrome of aberrant traits including mutation, sterility and male recombination. Genetics 86: 813–833.
McClintock, B. (1951). Chromosomal organisation and genetic expression Cold Spring Harb. Symp. quant. Biol. 16: 13–47.
McClintock, B. (1965). The control of gene action in maize. Brookhaven Symp. Biol. 18: 162–184.
Minamori, S. (1972). Extrachromosomal elements delta in Drosophila melanogaster. VIII. Inseparable association with sensitive second chromosomes. Genetics 70: 557–566.
Peterson, P. (1970). Controlling elements and mutable loci in maize: their relationships to bacterial episomes. Genetica 41: 33–56.
Plus, N. (1978): Viruses in Drosophila populations and their role in population genetics. XIV Intern. Cong. of Genetics. Contributed paper sessions, Abstracts, P.I. Sections 13–20. ‘Nauka’, Moscow, 475.
Plus, N., G. Groizier, F.X. Jousset & I. David (1975). Picorna-viruses of laboratory and wild Drosophila melanogaster; geographical distribution and serotypic composition. Annles Inst. Pasteur, Paris 126A: 107–117.
Spencer, W.P. (1935). The non-random nature of visible mutations in Drosophila. Am. Nat. 69: 223–238.
Sprague, G.F. & H.H. McKinney (1966). Aberrant ratio: an anomaly in maize associated with virus infection. Genetics 54: 1287–1296.
Sprague, G.F. & H.H. McKinney (1971). Further evidence on the genetic behavior of AR in maize. Genetics 67: 533–542.
Starlinger, P. & H. Saedler (1972). Insertion mutations in micro-organisms. Biochemie 54: 177–185.
Starlinger, P. & H. Saedler (1976). IS-elements in microorganisms. Current Topics in microbiology and immunology 75: 111–152.
Thompson, I.N. & R.C. Woodruff (1978). Mutator genes — pacemakers of evolution. Nature 274: 317–322.
Timofeeff-Resovsky, N.W. (1932). Mutations of the gene in different directions. Proc. VI Int. Conf. Genet. Ithaca. N.Y.: 308–330.
Vorontsov, N.N. (1973). Viruses as a cytogenetic mutagenic factor and their role in speciation of higher animals. Proc. I Int. Congr. Evolut. Biol. Biosystematics. Boulder: 113
White, M.J.D. (1978) Models of speciation. Science 154: 1065–1070.
Zieg, I., M. Silverman, M. Hilman & M. Simon (1977). Recombinational switch for gene expression. Science 196: 170–173.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Golubovsky, M.D. Mutational process and microevolution. Genetica 52, 139–149 (1980). https://doi.org/10.1007/BF00121824
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF00121824