Semi-crystalline poly-L-lactic acid (PLLA) wire was implanted intramedullary in rat tibiae to evaluate the fracture healing processes and the tissue reaction on the PLLA in a fractured bone. The fracture healing after PLLA implantation was compared to a sham-operated group of animals. In all animals with intramedullary PLLA wire implantation newly formed bone was seen immediately against the implant 2 and 6 months after implantation. None of the shamoperated animals showed newly formed intramedullary bone formation other than fracture healing callus and normal trabecular bone.
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Otto, T.E., Patka, P., Haarman, H.J.T.M. et al. Intramedullary bone formation after polylactic acid wire implantation. J Mater Sci: Mater Med 5, 407–410 (1994). https://doi.org/10.1007/BF00058974
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DOI: https://doi.org/10.1007/BF00058974