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Epinephrine and norepinephrine elevate 5′-monodeiodinase activity in rainbow trout liver slices

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Abstract

The 5′-monodeiodinase (5′-MDA) activity was measured in liver slices that were incubated for 3 hours with epinephrine (E) or norepinephrine (NE) in order to examine the influence of these catecholamine hormones on the regulation of hepatic monodeiodination of thyroxine (T4) in rainbow trout. Both E and NE induced a dose-dependent increase in 5′-MDA activity and in addition, E stimulated the release of T3 into the medium. In liver slices taken from trout that had been treated with the β-adrenoceptor inhibitor propranolol, the response to both E and NE was attenuated. The findings provide evidence of an action of these catecholamine hormones on the peripheral regulation of T3 production, and suggest that the control operatesvia the β-adrenoceptors.

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  1. Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, N1G 2W1, Canada

    S. E. Brett & J. F. Leatherland

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  1. S. E. Brett
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  2. J. F. Leatherland
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Brett, S.E., Leatherland, J.F. Epinephrine and norepinephrine elevate 5′-monodeiodinase activity in rainbow trout liver slices. Fish Physiol Biochem 16, 29–34 (1997). https://doi.org/10.1007/BF00004538

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