Advertisement

Journal of Analysis and Testing

, Volume 3, Issue 3, pp 253–259 | Cite as

Porous Ruthenium Selenide Nanoparticle as a Peroxidase Mimic for Glucose Bioassay

  • Wen Cao
  • Junshu Lin
  • Faheem Muhammad
  • Quan Wang
  • Xiaoyu Wang
  • Zhangping Lou
  • Hui WeiEmail author
Original Paper

Abstract

Nanozyme is a promising field that offers the substitution for natural enzymes using various nanomaterials. Various nanomaterials with peroxidase-like activity were investigated. Among them, transition metal chalcogenides were explored as promising nanozymes due to their excellent enzyme-mimicking activities. However, ruthenium selenide has not been studied as a peroxidase mimic because of the difficulty for synthesis. Herein, we prepared ruthenium selenide nanomaterial with ordered mesoporous structure (P-RuSe2) employing KIT-6 silica as the template. The composition and structure of P-RuSe2 were fully characterized. Further, its peroxidase-like activity was investigated. P-RuSe2 possessed excellent peroxidase-mimicking activity, which catalyzed the oxidation of peroxidase substrates, including 3,3′,5,5′-tetramethylbenzidine, o-phenylenediamine, and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) in the presence of H2O2. Moreover, P-RuSe2 exhibited higher peroxidase-like activity when compared with several representative nanozymes as well as bulk RuSe2. To demonstrate its potential applications, the colorimetric detection systems for H2O2 and glucose were successfully constructed based on P-RuSe2 nanozyme.

Keywords

Nanozymes Peroxidase mimics Artificial enzymes Ruthenium selenide Bionanotechnology Glucose bioassay 

Notes

Acknowledgements

This work was supported by National Natural Science Foundation of China (21874067 and 21722503), 973 Program (2015CB659400), PAPD program, Shuangchuang Program of Jiangsu Province, Open Funds of the State Key Laboratory of Analytical Chemistry for Life Science (SKLACLS1704), Open Funds of the State Key Laboratory of Coordination Chemistry (SKLCC1819), Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education) (ACBM2019001), and Fundamental Research Funds for the Central Universities (021314380145).

Supplementary material

41664_2019_104_MOESM1_ESM.docx (4.4 mb)
Supplementary material 1 (DOCX 4484 kb)

References

  1. 1.
    Wu JJX, et al. Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes (II). Chem Soc Rev. 2019;48:1004–76.Google Scholar
  2. 2.
    Breslow R. Biomimetic chemistry and artificial enzymes: catalysis by design. Acc Chem Res. 1995;28:146–53.Google Scholar
  3. 3.
    Gao LZ, et al. Intrinsic peroxidase-like activity of ferromagnetic nanoparticles. Nat Nanotechnol. 2007;2:577–83.Google Scholar
  4. 4.
    Wei H, et al. Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes. Chem Soc Rev. 2013;42:6060–93.PubMedGoogle Scholar
  5. 5.
    Zhou YB, et al. Filling in the gaps between nanozymes and enzymes: challenges and opportunities. Bioconjugate Chem. 2017;28:2903–9.Google Scholar
  6. 6.
    Lin YH, et al. Catalytically active nanomaterials: a promising candidate for artificial enzymes. Acc Chem Res. 2014;47:1097–105.PubMedGoogle Scholar
  7. 7.
    Zhang XZ, et al. Bioorthogonal nanozymes: progress towards therapeutic applications. Trends Chem. 2019;1:90–8.Google Scholar
  8. 8.
    Yan XY. Nanozyme: a new type of artificial enzyme. Prog Biochem Biophys. 2018;45:101–4.Google Scholar
  9. 9.
    Fan KL, et al. Magnetoferritin nanoparticles for targeting and visualizing tumour tissues. Nat Nanotechnol. 2012;7:459–64.PubMedGoogle Scholar
  10. 10.
    Song YJ, et al. Graphene oxide: intrinsic peroxidase catalytic activity and its application to glucose detection. Adv Mater. 2010;22:2206–10.PubMedGoogle Scholar
  11. 11.
    Tonga GY, et al. Supramolecular regulation of bioorthogonal catalysis in cells using nanoparticle-embedded transition metal catalysts. Nat Chem. 2015;7:597–603.PubMedPubMedCentralGoogle Scholar
  12. 12.
    Natalio F, et al. Vanadium pentoxide nanoparticles mimic vanadium haloperoxidases and thwart biofilm formation. Nat Nanotechnol. 2012;7:530–5.PubMedGoogle Scholar
  13. 13.
    Zhang ZJ, et al. Molecular imprinting on inorganic nanozymes for hundred-fold enzyme specificity. J Am Chem Soc. 2017;139:5412–9.PubMedGoogle Scholar
  14. 14.
    Soh M, et al. Ceria-zirconia nanoparticles as an enhanced multi-antioxidant for sepsis treatment. Angew Chem Int Ed. 2017;56:11399–403.Google Scholar
  15. 15.
    Chen JP, et al. Rare earth nanoparticles prevent retinal degeneration induced by intracellular peroxides. Nat Nanotechnol. 2006;1:142–50.PubMedGoogle Scholar
  16. 16.
    Vernekar AA, et al. An antioxidant nanozyme that uncovers the cytoprotective potential of vanadia nanowires. Nat Commun. 2014;5:5301.PubMedGoogle Scholar
  17. 17.
    Walther R, et al. Identification and directed development of non-organic catalysts with apparent pan-enzymatic mimicry into nanozymes for efficient prodrug conversion. Angew Chem Int Ed. 2019;58:278–82.Google Scholar
  18. 18.
    Sun MZ, et al. Site-selective photoinduced cleavage and profiling of DNA by chiral semiconductor nanoparticles. Nat Chem. 2018;10:821–30.PubMedGoogle Scholar
  19. 19.
    Fang G, et al. Differential Pd-nanocrystal facets demonstrate distinct antibacterial activity against Gram-positive and Gram-negative bacteria. Nat Commun. 2018;9:129.PubMedPubMedCentralGoogle Scholar
  20. 20.
    Shen XM, et al. Mechanisms of oxidase and superoxide dismutation-like activities of gold, silver, platinum, and palladium, and their alloys: a general way to the activation of molecular oxygen. J Am Chem Soc. 2015;137:15882–91.PubMedGoogle Scholar
  21. 21.
    Zhang W, et al. Prussian blue nanoparticles as multienzyme mimetics and reactive oxygen species scavengers. J Am Chem Soc. 2016;138:5860–5.PubMedGoogle Scholar
  22. 22.
    Xu ZB, et al. Converting organosulfur compounds to inorganic polysulfides against resistant bacterial infections. Nat Commun. 2018;9:3713.PubMedPubMedCentralGoogle Scholar
  23. 23.
    Wei H, et al. Fe3O4 magnetic nanoparticles as peroxidase mimetics and their applications in H2O2 and glucose detection. Anal Chem. 2008;80:2250–4.PubMedGoogle Scholar
  24. 24.
    Cheng HJ, et al. Integrated nanozymes with nanoscale proximity for in vivo neurochemical monitoring in living brains. Anal Chem. 2016;88:5489–97.PubMedGoogle Scholar
  25. 25.
    Hu YH, et al. Surface-enhanced raman scattering active gold nanoparticles with enzyme-mimicking activities for measuring glucose and lactate in living tissues. ACS Nano. 2017;11:5558–66.PubMedGoogle Scholar
  26. 26.
    Wang XY, et al. Boosting the peroxidase-like activity of nanostructured nickel by inducing its 3 + oxidation state in LaNiO3 perovskite and its application for biomedical assays. Theranostics. 2017;7:2277–86.PubMedPubMedCentralGoogle Scholar
  27. 27.
    Cheng HJ, et al. Monitoring of heparin activity in live rats using metal-organic framework nanosheets as peroxidase mimics. Anal Chem. 2017;89:11552–9.PubMedGoogle Scholar
  28. 28.
    Hu YH, et al. Nitrogen-doped carbon nanomaterials as highly active and specific peroxidase mimics. Chem Mater. 2018;30:6431–9.Google Scholar
  29. 29.
    Qin L, et al. 2D-metal-organic-framework-nanozyme sensor arrays for probing phosphates and their enzymatic hydrolysis. Anal Chem. 2018;90:9983–9.PubMedGoogle Scholar
  30. 30.
    Wang XY, et al. Nanozyme sensor arrays for detecting versatile analytes from small molecules to proteins and cells. Anal Chem. 2018;90:11696–702.Google Scholar
  31. 31.
    Wang XY, et al. e g occupancy as an effective descriptor for the catalytic activity of perovskite oxide-based peroxidase mimics. Nat Commun. 2019;10:704.PubMedPubMedCentralGoogle Scholar
  32. 32.
    Zhang WC, et al. Pd nanoparticle-decorated graphitic C3N4 nanosheets with bifunctional peroxidase mimicking and ON–OFF fluorescence enable naked-eye and fluorescent dual-readout sensing of glucose. J Mater Chem B. 2019;7:233–9.Google Scholar
  33. 33.
    Kong CJ, et al. Highly-active, graphene-supported platinum catalyst for the solventless hydrosilylation of olefins. Chem Commun. 2018;54:13343–6.Google Scholar
  34. 34.
    He YF, et al. A cobalt-based polyoxometalate nanozyme with high peroxidase-mimicking activity at neutral pH for one-pot colorimetric analysis of glucose. J Mater Chem B. 2018;6:5750–5.Google Scholar
  35. 35.
    Wang JJ, et al. Polyoxometalates as peroxidase mimetics and their applications in H2O2 and glucose detection. Biosens Bioelectron. 2012;36:18–21.PubMedGoogle Scholar
  36. 36.
    Huang LJ, et al. Portable colorimetric detection of Mercury (II) based on a non-noble metal nanozyme with tunable activity. Inorg Chem. 2019;58:1638–46.Google Scholar
  37. 37.
    Shi WB, et al. Carbon nanodots as peroxidase mimetics and their applications to glucose detection. Chem Commun. 2011;47:6695–7.Google Scholar
  38. 38.
    Vernekar AA, et al. Vacancy-engineered nanoceria: enzyme mimetic hotspots for the degradation of nerve agents. Angew Chem Int Ed. 2016;55:1412–6.Google Scholar
  39. 39.
    Wang QQ, et al. GOx@ ZIF-8 (NiPd) nanoflower: an artificial enzyme system for tandem catalysis. Angew Chem Int Ed. 2017;56:16082–5.Google Scholar
  40. 40.
    Wu YH, et al. Ultra-small particles of iron oxide as peroxidase for immunohistochemical detection. Nanotechnology. 2011;22:225703.PubMedGoogle Scholar
  41. 41.
    Dutta AK, et al. CuS nanoparticles as a mimic peroxidase for colorimetric estimation of human blood glucose level. Talanta. 2013;107:361–7.PubMedGoogle Scholar
  42. 42.
    Guan JF, et al. Synthesis of copper sulfide nanorods as peroxidase mimics for colorimetric detection of hydrogen peroxide. Anal Methods. 2015;7:5454–61.Google Scholar
  43. 43.
    He WW, et al. Understanding the formation of CuS concave superstructures with peroxidase-like activity. Nanoscale. 2012;4:3501–6.PubMedGoogle Scholar
  44. 44.
    Lin TR, et al. Visual detection of blood glucose based on peroxidase-like activity of WS2 nanosheets. Biosens Bioelectron. 2014;62:302–7.PubMedGoogle Scholar
  45. 45.
    Chen Q, et al. Hemin-functionalized WS2 nanosheets as highly active peroxidase mimetics for label-free colorimetric detection of H2O2 and glucose. Analyst. 2015;140:2857–63.PubMedGoogle Scholar
  46. 46.
    Bai Y, et al. Novel magnetic nickel telluride nanowires decorated with thorns: synthesis and their intrinsic peroxidase-like activity for detection of glucose. Chem Commun. 2014;50:13589–91.Google Scholar
  47. 47.
    Zhao K, et al. SDS-MoS2 nanoparticles as highly-efficient peroxidase mimetics for colorimetric detection of H2O2 and glucose. Talanta. 2015;141:47–52.PubMedGoogle Scholar
  48. 48.
    Lin TR, et al. Seeing diabetes: visual detection of glucose based on the intrinsic peroxidase-like activity of MoS2 nanosheets. Nanoscale. 2014;6:11856–62.PubMedGoogle Scholar
  49. 49.
    Wang WJ, et al. Synthesis of Au-WS2 nanocomposites and study on its peroxidase mimic activity. Chin J Anal Chem. 2018;46:1545–51.Google Scholar
  50. 50.
    Niu XH, et al. Uncapped nanobranch-based CuS clews used as an efficient peroxidase mimic enable the visual detection of hydrogen peroxide and glucose with fast response. Anal Chim Acta. 2016;947:42–9.PubMedGoogle Scholar
  51. 51.
    Ye HH, et al. Peroxidase-like properties of ruthenium nanoframes. Sci Bull. 2016;61:1739–45.Google Scholar
  52. 52.
    Deng HM, et al. Nanoparticulate peroxidase/catalase mimetic and its application. Chem Eur J. 2012;18:8906–11.PubMedGoogle Scholar
  53. 53.
    Xia XH, et al. Pd-Ir core-shell nanocubes: a type of highly efficient and versatile peroxidase mimic. ACS Nano. 2015;9:9994–10004.PubMedGoogle Scholar
  54. 54.
    Jang JH, et al. Superior oxygen electrocatalysis on RuSex nanoparticles for rechargeable air cathodes. Adv Energy Mater. 2018;8:1702037.Google Scholar
  55. 55.
    Cai HY, et al. Bifacial dye-sensitized solar cells with enhanced rear efficiency and power output. Nanoscale. 2014;6:15127–33.PubMedGoogle Scholar
  56. 56.
    Li PJ, et al. Counter electrodes from binary ruthenium selenide alloys for dye-sensitized solar cells. J Power Sources. 2014;271:108–13.Google Scholar
  57. 57.
    Guo YJ, et al. Hemin-graphene hybrid nanosheets with intrinsic peroxidase-like activity for label-free colorimetric detection of single-nucleotide polymorphism. ACS Nano. 2011;5:1282–90.PubMedGoogle Scholar
  58. 58.
    Chaudhari KN, et al. Peroxidase mimic activity of hematite iron oxides (α-Fe2O3) with different nanostructures. Catal Sci Technol. 2012;2:119–24.Google Scholar
  59. 59.
    Liu BW, et al. Accelerating peroxidase mimicking nanozymes using DNA. Nanoscale. 2015;7:13831–5.PubMedGoogle Scholar
  60. 60.
    Zhang XQ, et al. Prussian blue modified iron oxide magnetic nanoparticles and their high peroxidase-like activity. J Mater Chem. 2010;20:5110–6.Google Scholar
  61. 61.
    Kleitz F, et al. Cubic Ia3d large mesoporous silica: synthesis and replication to platinum nanowires, carbon nanorods and carbon nanotubes. Chem Commun. 2003;17:2136–7.Google Scholar
  62. 62.
    Shen J, et al. An ESCA study of the interaction of oxygen with the surface of ruthenium. Appl Surf Sci. 1991;51:47–60.Google Scholar
  63. 63.
    Li HY, et al. Simple microwave preparation of high activity Se-rich CoSe2/C for oxygen reduction reaction. Electrochim Acta. 2014;138:232–9.Google Scholar

Copyright information

© The Nonferrous Metals Society of China 2019

Authors and Affiliations

  • Wen Cao
    • 1
    • 3
  • Junshu Lin
    • 1
    • 2
    • 3
  • Faheem Muhammad
    • 1
    • 3
  • Quan Wang
    • 1
    • 3
  • Xiaoyu Wang
    • 1
    • 3
  • Zhangping Lou
    • 1
    • 3
  • Hui Wei
    • 1
    • 2
    • 3
    Email author
  1. 1.Department of Biomedical Engineering, College of Engineering and Applied Sciences, Nanjing National Laboratory of Microstructures, Jiangsu Key Laboratory of Artificial Functional MaterialsNanjing UniversityNanjingChina
  2. 2.Department of Biomaterials, College of MaterialsXiamen UniversityXiamenChina
  3. 3.State Key Laboratory of Analytical Chemistry for Life Science and State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical EngineeringNanjing UniversityNanjingChina

Personalised recommendations