Abstract
Clozapine, an atypical antipsychotic, has recently become available in the USA in the form of an oral suspension (Versacloz™). The oral suspension formulation has several potential advantages over traditional tablet formulations. The efficacy of clozapine in the treatment of treatment-resistant schizophrenia, and in reducing suicidal behavior in patients with schizophrenia or schizoaffective disorder, is well-established. Although its use has been limited by its association with serious hematological toxicity, it is considered the antipsychotic of choice in patients with treatment-resistant schizophrenia, and is also of benefit in reducing suicidal behavior in patients with schizophrenia or schizoaffective disorder.
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Acknowledgments
The manuscript was reviewed by: M. Hahn, Vitos Rheingau, Eltville, Germany; E. Obarcanin, Sarajevo, Bosnia and Herzegovina; S. Saluja, Consultant in Internal Medicine, Saran Ashram, Agra, India.
Disclosure
The preparation of this article was not supported by any external funding. K.A. Lyseng-Williamson is a salaried employee of Adis/Springer. During the review process, the manufacturer of the agent under review was offered an opportunity to comment on the article. Changes resulting from comments received were made by the author on the basis of scientific and editorial merit.
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Lyseng-Williamson, K.A. Clozapine oral suspension (Versacloz™): a guide to its use in the USA. Drugs Ther Perspect 30, 193–199 (2014). https://doi.org/10.1007/s40267-014-0124-6
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DOI: https://doi.org/10.1007/s40267-014-0124-6