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Clinicopathological features of gastric adenocarcinoma patients with metachronous distant metastasis

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Tumor Biology

Abstract

Metachronous distant metastasis influences the postoperative survival of gastric adenocarcinoma patients with radical gastrectomy. We retrospectively reviewed 108 gastric adenocarcinoma patients with metachronous distant metastasis admitted to our hospital between January 2006 and December 2011. First, these patients were divided into two groups according to the time of metastasis: the early metastasis group (EMG) and late metastasis group (LMG). Second, according to the survival time after metastasis, these patients were divided into the longer survival group (LSG) and shorter survival group (SSG). Chi-square and Fisher exact tests were used to analyze associations between categorical variables. Survival data were estimated using the Kaplan–Meier method. Multivariate analyses of the prognostic factors related to overall survival were conducted using the Cox stepwise proportional hazards test. Results shows that the EMG was significantly associated with depth of invasion (p = 0.005), Union for International Cancer Control (UICC) stage (p = 0.003), degree of differentiation (p = 0.002), and vascular invasion (p = 0.001). The SSG was significantly associated with depth of invasion (p = 0.026) and normal carcinoembryonic antigen (CEA) level of after metastasis (p = 0.003). Survival analysis showed that depth of invasion (p < 0.001), degree of differentiation (p = 0.001), and vascular invasion (p = 0.011) were independent prognostic factors for gastric adenocarcinoma patients with metachronous distant metastasis. Gastric adenocarcinoma patients with metachronous distant metastasis exhibit characteristics that can be used to effectively estimate the possibility of early distant metastasis and the prognosis of these patients.

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Acknowledgments

This study was supported by a grant from The Third Affiliated Hospital of Harbin Medical University. The authors thank Yang Gao, Shanshan Sun, and Rui Xie for excellent assistances.

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Authors and Affiliations

  1. Department of Gastroenterologic Surgery, Harbin Medical University Cancer Hospital, 150 Haping Road, Nan Gang District, Harbin, China

    Junjie Bao, Haibin Song, Yuzhe Wei & Yingwei Xue

  2. Department of Orthopedics Department, Harbin Medical University Cancer Hospital, Harbin, China

    Guofan Qu

  3. Department of Pharmacy, The First Clinical Medical College of Harbin Medical University, Harbin, China

    Wangshu Fu

  4. Department of Gastrointestinal Oncology, Harbin Medical University Cancer Hospital, Harbin, China

    Yanjing Li

Authors
  1. Junjie Bao
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  2. Guofan Qu
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  3. Wangshu Fu
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  4. Yanjing Li
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  5. Haibin Song
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  6. Yuzhe Wei
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  7. Yingwei Xue
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Correspondence to Yingwei Xue.

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Bao, J., Qu, G., Fu, W. et al. Clinicopathological features of gastric adenocarcinoma patients with metachronous distant metastasis. Tumor Biol. 36, 6375–6382 (2015). https://doi.org/10.1007/s13277-015-3325-2

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  • DOI: https://doi.org/10.1007/s13277-015-3325-2

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