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Feasibility of data-driven cardiac respiratory motion correction of myocardial perfusion CZT SPECT: A pilot study

  • Original Article
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Journal of Nuclear Cardiology Aims and scope

Abstract

Background

We developed a data-driven respiratory motion (RM) correction method (REGAT program) for multiple-pinhole detector CZT SPECT. We verified its clinical feasibility with myocardial perfusion imaging (MPI) and studied its impact on image characteristics.

Methods

This retrospective study included 18 patients having stress/rest 99mTc-Tetrofosmin MPI SPECT. List mode was acquired on CZT SPECT and processed with REGAT. REGAT generates reconstructed RM-gated volumes that are summed either without realignment (NR-SPECT) or after realignment (R-SPECT). For both stress and rest, we calculated the maximal RM in the 3 axis, and image characteristics of both R-SPECT and NR-SPECT: minimum left ventricular (LV) cavity counts (LV-Min), maximum LV myocardial counts (LV-Max), LV contrast, and FWHM of both anterior (FWHM-ant) and inferior (FWHM-inf) LV myocardial walls.

Results

At both stress and rest, cranio-caudal motion was the dominant axial movement and REGAT had a positive impact on image characteristics as reflected by variations between R-SPECT and NR-SPECT in LV-Min, LV-Max, FWHM-ant, FWHM-inf, and contrast. These latter were well correlated to the amplitude of cranio-caudal motion at both stress and rest.

Conclusions

Data-driven RM correction of MPI acquired with CZT SPECT is clinically feasible and easily applicable. It presents interesting impact on image characteristics.

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Abbreviations

RM:

Respiratory motion

MPI:

Myocardial perfusion imaging

LV:

Left ventricle

R-SPECT:

Realigned SPECT

NR-SPECT:

Non-realigned SPECT

LV-Min:

Minimum left ventricular cavity counts

LV-Max:

Maximum LV myocardial counts

FWHM-ant:

FWHM of anterior myocardial wall

FWHM-inf:

FWHM of inferior myocardial wall

REGAT:

Respiratory gating software

References

  1. Buechel RR, Pazhenkottil AP, Herzog BA, et al. Real-time breath-hold triggering of myocardial perfusion imaging with a novel cadmium-zinc-telluride detector gamma camera. Eur J Nucl Med Mol Imaging 2010;37:1903–8.

    Article  PubMed  Google Scholar 

  2. Cho K, Kumiata S, Okada S, Kumazaki T. Development of respiratory gated myocardial SPECT system. J Nucl Cardiol 1999;6:20–8.

    Article  CAS  PubMed  Google Scholar 

  3. Segars WP, Tsui BMW. Study of the efficacy of respiratory gating in myocardial SPECT using the new 4-D NCAT. IEEE Trans Nucl Sci 2000;47:1192–5.

    Article  Google Scholar 

  4. Livieratos L, Rajappan K, Stegger L, Schafers K, Bailey DL, Camici PG. Respiratory gating of cardiac PET data in list-mode acquisition. Eur J Nucl Med Mol Imaging 2006;33:584–8.

    Article  PubMed  Google Scholar 

  5. Kovalski G, Israel O, Keidar Z, Frenkel A, Sachs J, Azhari H. Correction of heart motion due to respiration in clinical myocardial perfusion SPECT scans using respiratory gating. J Nucl Med 2007;48:630–6.

    Article  PubMed  Google Scholar 

  6. Martinez-Moller A, Zikic D, Botnar RM, et al. Dual cardiac-respiratory gated PET: Implementation and results from a feasibility study. Eur J Nucl Med Mol Imaging 2007;34:1447–54.

    Article  PubMed  Google Scholar 

  7. Ko CL, Wu YW, Cheng MF, Yen RF, Wu WC, Tzen KY. Data-driven respiratory motion tracking and compensation in CZT cameras: A comprehensive analysis of phantom and human images. J Nucl Cardiol 2015;22:308–18.

    Article  PubMed  Google Scholar 

  8. Bocher M, Blevis IM, Tsukerman L, Shrem Y, Kovalski G, Volokh L. A fast cardiac gamma camera with dynamic SPECT capabilities: Design, system validation and future potential. Eur J Nucl Med Mol Imaging 2010;37:1887–902.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Tawileh M. Development of an optimal method for respiratory gating in nuclear medicine. PhD thesis, University Paris XII, July 2009.

  10. Daou D, Tawileh M, Khiar-Dechmi A, Coaguila C. Myocardial perfusion imaging with conventional gamma camera: To what level do data-driven, video and belt respiratory motion curves correlate? [abstract]. J Nucl Med 2015;56:1798P.

    Google Scholar 

  11. Tanaka H, Chikamori T, Tanaka N, et al. Diagnostic performance of a novel cadmium-zinc-telluride gamma camera system assessed using fractional flow reserve. Circ J 2014;78:2727–34.

    Article  PubMed  Google Scholar 

  12. Duvall WL, Sweeny JM, Croft LB, et al. Comparison of high efficiency CZT SPECT MPI to coronary angiography. J Nucl Cardiol 2011;18:595–604.

    Article  PubMed  Google Scholar 

  13. Duvall WL, Sweeny JM, Croft LB, Ginsberg E, Guma KA, Henzlova MJ. Reduced stress dose with rapid acquisition CZT SPECT MPI in a non-obese clinical population: Comparison to coronary angiography. J Nucl Cardiol 2012;19:19–27.

    Article  PubMed  Google Scholar 

  14. Gimelli A, Bottai M, Genovesi D, Giorgetti A, Di Martino F, Marzullo P. High diagnostic accuracy of low-dose gated-SPECT with solid-state ultrafast detectors: Preliminary clinical results. Eur J Nucl Med Mol Imaging 2012;39:83–90.

    Article  CAS  PubMed  Google Scholar 

  15. Buechel RR, Herzog BA, Husmann L, et al. Ultrafast nuclear myocardial perfusion imaging on a new gamma camera with semiconductor detector technique: First clinical validation. Eur J Nucl Med Mol Imaging 2010;37:773–8.

    Article  PubMed  Google Scholar 

  16. Fiechter M, Ghadri JR, Kuest SM, et al. Nuclear myocardial perfusion imaging with a novel cadmium-zinc-telluride detector SPECT/CT device: First validation versus invasive coronary angiography. Eur J Nucl Med Mol Imaging 2011;38:2025–30.

    Article  CAS  PubMed  Google Scholar 

  17. Mouden M, Ottervanger JP, Knollema S, et al. Myocardial perfusion imaging with a cadmium zinc telluride-based gamma camera versus invasive fractional flow reserve. Eur J Nucl Med Mol Imaging 2014;41:956–62.

    Article  CAS  PubMed  Google Scholar 

  18. Daou D. Respiratory motion handling is mandatory to accomplish the high-resolution PET destiny [editorial]. Eur J Nucl Med Mol Imaging 2008;35:1961–70.

    Article  PubMed  Google Scholar 

  19. McLeish K, Hill DL, Atkinson D, Blackall JM, Razavi R. A study of the motion and deformation of the heart due to respiration. IEEE Trans Med Imaging 2002;21:1142–50.

    Article  PubMed  Google Scholar 

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Disclosure

Doumit Daou, Rémy Sabbah, Carlos Coaguila, and Hatem Boulahdour have no conflict of interest.

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Authors and Affiliations

  1. EA 7334 REMES, Université Paris-Diderot, Sorbonne Paris-Cité, Paris, France

    Doumit Daou MD, PhD

  2. Nuclear Medicine Department, Cochin University Hospital, AP-HP, 27 rue du Faubourg Saint-Jacques, 75679, Paris Cedex 14, France

    Doumit Daou MD, PhD

  3. Nuclear Medicine Department, CHU Jean Minjoz, Besançon, France

    Rémy Sabbah MD & Hatem Boulahdour MD, PhD

  4. Nuclear Medicine Department, Centre Hospitalier de Bigorre, Tarbes, France

    Carlos Coaguila MD

Authors
  1. Doumit Daou MD, PhD
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  2. Rémy Sabbah MD
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  3. Carlos Coaguila MD
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  4. Hatem Boulahdour MD, PhD
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Corresponding author

Correspondence to Doumit Daou MD, PhD.

Additional information

See related editorial, doi:10.1007/s12350-016-0542-z.

All editorial decisions for this article, including selection of reviewers and the final decision, were made by guest editor Alberto Cuocolo, MD.

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Daou, D., Sabbah, R., Coaguila, C. et al. Feasibility of data-driven cardiac respiratory motion correction of myocardial perfusion CZT SPECT: A pilot study. J. Nucl. Cardiol. 24, 1598–1607 (2017). https://doi.org/10.1007/s12350-016-0493-4

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  • DOI: https://doi.org/10.1007/s12350-016-0493-4

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