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Relief from vascular occlusion using photothermal ablation of thrombus with a multimodal perspective

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Abstract

Fibrinolytic therapy for arterial or venous thrombotic disorders involves the systemic administration of thrombolytics such as streptokinase, which is associated with serious bleeding complications. With this study, we provide a proof-of-concept of photothermal thrombus ablation with gold nanorods exposed to near-infrared irradiation, both in vitro using materials generated from purified fibrinogen or plasma and in vivo in murine blood vessels. This is the first report of the application of photothermal therapy as an anti-thrombotic measure. Remarkably, the addition of streptokinase had a multimodal additive effect with regard to acceleration of photothermal lysis of thrombi even at a dose significantly below the therapeutic concentration, thus minimizing the life-threatening side effects and adverse complications. This combinatorial approach exhibits great promise for lysing pathological clots while effectively overcoming the drawbacks of existing therapies.

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Authors and Affiliations

  1. Department of Biochemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India

    Nitesh Singh, Anand Varma & Debabrata Dash

  2. Department of Radiodiagnosis and Imaging, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India

    Ashish Verma & Babu N. Maurya

Authors
  1. Nitesh Singh
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  2. Anand Varma
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  3. Ashish Verma
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  4. Babu N. Maurya
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  5. Debabrata Dash
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Correspondence to Debabrata Dash.

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These authors contributed equally to this work.

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Singh, N., Varma, A., Verma, A. et al. Relief from vascular occlusion using photothermal ablation of thrombus with a multimodal perspective. Nano Res. 9, 2327–2337 (2016). https://doi.org/10.1007/s12274-016-1119-5

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  • DOI: https://doi.org/10.1007/s12274-016-1119-5

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