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Impaired Hypothalamic Regulation of Sympathetic Outflow in Primary Hypertension

  • Jing-Jing Zhou
  • Hui-Jie Ma
  • Jian-Ying Shao
  • Hui-Lin Pan
  • De-Pei Li
Review
  • 13 Downloads

Abstract

The hypothalamic paraventricular nucleus (PVN) is a crucial region involved in maintaining homeostasis through the regulation of cardiovascular, neuroendocrine, and other functions. The PVN provides a dominant source of excitatory drive to the sympathetic outflow through innervation of the brainstem and spinal cord in hypertension. We discuss current findings on the role of the PVN in the regulation of sympathetic output in both normotensive and hypertensive conditions. The PVN seems to play a major role in generating the elevated sympathetic vasomotor activity that is characteristic of multiple forms of hypertension, including primary hypertension in humans. Recent studies in the spontaneously hypertensive rat model have revealed an imbalance of inhibitory and excitatory synaptic inputs to PVN pre-sympathetic neurons as indicated by impaired inhibitory and enhanced excitatory synaptic inputs in hypertension. This imbalance of inhibitory and excitatory synaptic inputs in the PVN forms the basis for elevated sympathetic outflow in hypertension. In this review, we discuss the disruption of balance between glutamatergic and GABAergic inputs and the associated cellular and molecular alterations as mechanisms underlying the hyperactivity of PVN pre-sympathetic neurons in hypertension.

Keywords

Hypothalamus Paraventricular nucleus Synaptic plasticity Essential hypertension Sympathetic nervous system 

Notes

Acknowledgements

The studies conducted in the authors’ laboratories were supported by National Institutes of Health Grants HL131161, HL139523, and HL142133.

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Copyright information

© Shanghai Institutes for Biological Sciences, CAS and Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Jing-Jing Zhou
    • 1
  • Hui-Jie Ma
    • 1
    • 2
  • Jian-Ying Shao
    • 1
  • Hui-Lin Pan
    • 1
  • De-Pei Li
    • 3
  1. 1.Division of Anesthesiology and Critical CareThe University of Texas MD Anderson Cancer CenterHoustonUSA
  2. 2.Department of PhysiologyHebei Medical UniversityShijiazhuangChina
  3. 3.Department of Medicine, Center for Precision MedicineUniversity of MissouriColumbiaUSA

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