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The rs2228570 Variant of the Vitamin D Receptor Gene is Associated with Essential Tremor

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References

  1. Sazci A, Ergul E, Bayulkem K. Association of the C677T and A1298C polymorphisms of methylenetetrahydrofolate reductase gene in patients with essential tremor in Turkey. Mov Disord 2004, 19: 1472–1476.

    Article  PubMed  Google Scholar 

  2. Deng H, Wang P, Jankovic J. The genetics of Parkinson disease. Ageing Res Rev 2017, 42: 72–85.

    Article  CAS  PubMed  Google Scholar 

  3. Pahwa R, Lyons KE. Essential tremor: differential diagnosis and current therapy. Am J Med 2003, 115: 134–142.

    Article  PubMed  Google Scholar 

  4. Chen JJ, Swope DM. Essential tremor: diagnosis and treatment. Pharmacotherapy 2003, 23: 1105–1122.

    Article  PubMed  Google Scholar 

  5. Gulcher JR, Jonsson P, Kong A, Kristjansson K, Frigge ML, Karason A, et al. Mapping of a familial essential tremor gene, FET1, to chromosome 3q13. Nat Genet 1997, 17: 84–87.

    Article  CAS  PubMed  Google Scholar 

  6. Higgins JJ, Pho LT, Nee LE. A gene (ETM) for essential tremor maps to chromosome 2p22-p25. Mov Disord 1997, 12: 859–864.

    Article  CAS  PubMed  Google Scholar 

  7. Shatunov A, Sambuughin N, Jankovic J, Elble R, Lee HS, Singleton AB, et al. Genomewide scans in North American families reveal genetic linkage of essential tremor to a region on chromosome 6p23. Brain 2006, 129(Pt 9): 2318–2331.

    Article  PubMed  Google Scholar 

  8. Louis ED, Yi H, Erickson-Davis C, Vonsattlel JP, Faust PL. Structural study of Purkinje cell axonal torpedoes in essential tremor. Neurosci Lett 2009, 450: 287–291.

    Article  CAS  PubMed  Google Scholar 

  9. Fang W, Chen H, Wang H, Zhang H, Puneet M, Liu M, et al. Essential tremor is associated with disruption of functional connectivity in the ventral intermediate nucleus- motor cortex-cerebellum circuit. Hum Brain Mapp 2016, 37: 165–178.

    Article  PubMed  Google Scholar 

  10. Stefansson H, Steinberg S, Petursson H, Gustafsson O, Gudjonsdottir IH, Jonsdottir GA, et al. Variant in the sequence of the LINGO1 gene confers risk of essential tremor. Nat Genet 2009, 41(3): 277–279. Erratum in: Nat Genet 2009, 41: 504.

  11. Arai H, Miyamoto K, Taketani Y, Yamamoto H, Iemori Y, Morita K, et al. A vitamin D receptor gene polymorphism in the translation initiation codon: effect on protein activity and relation to bone mineral density in Japanese women. J Bone Miner Res 1997, 12: 915–921.

    Article  CAS  PubMed  Google Scholar 

  12. Jurutka PW, Remus LS, Whitfield GK, Thompson PD, Hsieh JC, Zitzer H, et al. The polymorphic N terminus in human vitamin D receptor isoforms influences transcriptional activity by modulating interaction with transcription factor IIB. Mol Endocrinol 2000, 14: 401–420.

    Article  CAS  PubMed  Google Scholar 

  13. Shen L, Jia J. An overview of genome-wide association studies in Alzheimer’s disease. Neurosci Bull 2016, 32: 183–190.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Berridge MJ. Vitamin D cell signalling in health and disease. Biochem Biophys Res Commun 2015, 460: 53–71.

    Article  CAS  PubMed  Google Scholar 

  15. Burne TH, McGrath JJ, Eyles DW, Mackay-Sim A. Behavioural characterization of vitamin D receptor knockout mice. Behav Brain Res 2005, 157: 299–308.

    Article  CAS  PubMed  Google Scholar 

  16. Basit S. Vitamin D in health and disease: a literature review. Br J Biomed Sci 2013, 70: 161–172.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Medical Biology and Genetics, Faculty of Medicine, University of Kocaeli, 41380, Kocaeli, Turkey

    Ali Sazci, Nihal Uren & Emel Ergul

  2. Department of Neurology, Istanbul Faculty of Medicine, University of Istanbul, Capa, 34260, Istanbul, Turkey

    Halil Atilla Idrisoglu

Authors
  1. Ali Sazci
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  2. Nihal Uren
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  3. Halil Atilla Idrisoglu
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  4. Emel Ergul
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Correspondence to Ali Sazci.

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Sazci, A., Uren, N., Idrisoglu, H.A. et al. The rs2228570 Variant of the Vitamin D Receptor Gene is Associated with Essential Tremor. Neurosci. Bull. 35, 362–364 (2019). https://doi.org/10.1007/s12264-018-0287-6

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  • DOI: https://doi.org/10.1007/s12264-018-0287-6

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