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Method validation parameters for drugs and explosives in ambient pressure ion mobility spectrometry

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International Journal for Ion Mobility Spectrometry

Abstract

An approach using method validation (MV) parameters, otherwise known as analytical figures of merit was combined with electrospray ionization high performance ion mobility spectrometry (ESI-HPIMS) to describe an approach for evaluating drugs and explosives analysis in the field. MV parameters such as reduced mobility (K o ), conditional reduced mobility (K c ), resolving power (R p ), theoretical plates (N), linearity, accuracy, precision, limit of detection (LOD), limit of quantitation (LOQ), repeatability, range, and reporting limit were investigated and developed for eleven drugs and six explosives. Our investigation estimated resolving power at 66 ± 0.64 for the ESI-HPIMS used. The LOD’s calculated ranged from 0.45–2.97 ng of material electrosprayed into the ESI-HPIMS. The LOQ’s calculated falls in the range 4.11–8.63 ng of material electrosprayed into the ESI-HPIMS. The key findings from this investigation were the following: K c proves to be a measure of the identity of an explosive or drug ion; a parameter that may be applied to help aid IMS devices when detecting drugs and explosives. MV parameters, especially, K c , introduced in this study is an effective parameter for establishing a unique identity of a drug or explosive. A control chart is an effective way to monitor the performance of an instrument and may be a useful tool for establishing reliability of confirmatory data in forensic investigations. MV parameters may be a reliable, accurate and unique identification marker for target drugs and explosives capable of differentiating these substances from false positive responses.

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Acknowledgements

We gratefully acknowledge the support of the Professional Development Committee (PDC) at Winston-Salem State University for their support of this work. The authors also thank Mr. David Pollard for his support during this investigation.

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  1. Department of Chemistry, Winston-Salem State University, Winston-Salem, NC, 27110, USA

    Victoria Sedwick, Monique Massey, TeAsia Codio & A Bakarr Kanu

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  1. Victoria Sedwick
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Correspondence to A Bakarr Kanu.

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Sedwick, V., Massey, M., Codio, T. et al. Method validation parameters for drugs and explosives in ambient pressure ion mobility spectrometry. Int. J. Ion Mobil. Spec. 20, 75–86 (2017). https://doi.org/10.1007/s12127-017-0221-z

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  • DOI: https://doi.org/10.1007/s12127-017-0221-z

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