The most common sites of metastatic differentiated thyroid cancer are the neck lymph nodes, while distant metastases typically involve the lungs, the bones, and less frequently the brain. Uncommon metastatic sites include the liver, adrenal gland, kidney, pancreas, and skin. The epidemiological aspects of thyroid metastases in rare sites are largely unknown and their identification could have a significant impact on patients management. A mini-series of unusual metastatic sites of thyroid carcinoma is proposed as a contribution to current knowledge on anatomopathological characteristics and clinical outcome. Of the six cases that were assessed, the metastases were the following: skin metastases (2), skin and pancreas metastases (1), renal metastasis (1), adrenal metastasis (1), and liver metastasis (1). In our experience, metastases in rare sites do not always represent a negative prognostic factor for disease outcome. In fact they can occur as single distant lesion and if surgically resectable, their treatment can also lead to local disease remission.
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The authors are grateful to Milly Buwenge B.Sc. for reviewing the manuscript and to Paolo Cipressi and Cinzia Giacometti for their contribution in graphic art.
Compliance with Ethical Standards
The manuscript has no funding.
Conflicts of Interest
The authors declare that they have no competing interests.
The study was approved by the local Ethics Committee.
Informed consent was obtained from all individual participants included in the study.
This article does not contain any studies with human participants or animals performed by any of the authors.
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