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Therapeutic Application of Adipose Derived Stem Cells in Acute Myocardial Infarction: Lessons from Animal Models

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Abstract

The majority of patients survive an acute myocardial infarction (AMI). Their outcome is negatively influenced by post-AMI events, such as loss of viable cardiomyocytes due to a post-AMI inflammatory response, eventually resulting in heart failure and/or death. Recent pre-clinical animal studies indicate that mesenchymal stem cells derived from adipose tissue (ASC) are new promising candidates that may facilitate cardiovascular regeneration in the infarcted myocardium. In this review we have compared all animal studies in which ASC were used as a therapy post-AMI and have focused on aspects that might be important for future successful clinical application of ASC.

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Abbreviations

ASC:

Adipose derived stem cell

AMI:

Acute myocardial infarction

IV:

Intravenous injection

IC:

Intracoronary injection

IM:

Intramyocardial injection

MSC:

Mesenchymal stem cell

BMSC:

Bone marrow derived mesenchymal stem cell

SVF:

Stromal vascular fraction

LVEF:

Left ventricular ejection fraction

I/R:

Ischemia/reperfusion

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Conflict of Interest

The authors indicate no potential conflicts of interest.

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Authors and Affiliations

  1. Department of Pathology, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands

    B. A. Naaijkens, A. van Dijk, P. A. J. Krijnen & H. W. M. Niessen

  2. Department of Cardiac Surgery, VU University Medical Center, Amsterdam, The Netherlands

    H. W. M. Niessen

  3. Department of Physiology, VU University Medical Center, Amsterdam, The Netherlands

    L. J. M. Juffermans

  4. Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands

    O. Kamp & L. J. M. Juffermans

  5. Institute of Cardiovascular Research (ICaR-VU), VU University Medical Center, Amsterdam, The Netherlands

    B. A. Naaijkens, A. van Dijk, O. Kamp, P. A. J. Krijnen, H. W. M. Niessen & L. J. M. Juffermans

  6. Interuniversity Cardiology Institute of the Netherlands (ICIN), Utrecht, The Netherlands

    B. A. Naaijkens, O. Kamp & L. J. M. Juffermans

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  1. B. A. Naaijkens
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  2. A. van Dijk
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  3. O. Kamp
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  4. P. A. J. Krijnen
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  5. H. W. M. Niessen
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  6. L. J. M. Juffermans
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Correspondence to B. A. Naaijkens.

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Naaijkens, B.A., van Dijk, A., Kamp, O. et al. Therapeutic Application of Adipose Derived Stem Cells in Acute Myocardial Infarction: Lessons from Animal Models. Stem Cell Rev and Rep 10, 389–398 (2014). https://doi.org/10.1007/s12015-014-9502-7

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  • DOI: https://doi.org/10.1007/s12015-014-9502-7

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