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Mechanobiology of Bone Metastatic Cancer

  • Biomechanics (J Nyman and C Hernandez, Section Editors)
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Abstract

Purpose of Review

In this review, we provide an overview of what is currently known about the impacts of mechanical stimuli on metastatic tumor-induced bone disease (TIBD). Further, we focus on the role of the osteocyte, the skeleton’s primary mechanosensory cell, which is central to the skeleton’s mechanoresponse, sensing and integrating local mechanical stimuli, and then controlling the downstream remodeling balance as appropriate.

Recent Findings

Exercise and controlled mechanical loading have anabolic effects on bone tissue in models of bone metastasis. They also have anti-tumorigenic properties, in part due to offsetting the vicious cycle of osteolytic bone loss as well as regulating inflammatory signals. The impacts of metastatic cancer on the mechanosensory function of osteocytes remains unclear.

Summary

Increased mechanical stimuli are a potential method for mitigating TIBD.

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Data availability

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Funding

Cancer League of Colorado (ML, PO), National Science Foundation CMMI 2047187 (ML), Veteran’s Affairs Grant 1KBX00002929 (PO). CI supported by NIH/NCATS Colorado CTSA Grant Number TL1 TR002533; Contents are the authors’ sole responsibility and do not necessarily represent official NIH views.

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Authors and Affiliations

  1. Department of Mechanical Engineering, University of Colorado, 427 UCB, Boulder, CO, 80309, USA

    Blayne A. Sarazin & Maureen E. Lynch

  2. Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA

    Claire L. Ihle & Philip Owens

  3. Department of Veterans Affairs, Research Service, Eastern Colorado Health Care System, Aurora, CO, 80045, USA

    Philip Owens

  4. Biofrontiers Institute, University of Colorado, Boulder, CO, 80309, USA

    Maureen E. Lynch

Authors
  1. Blayne A. Sarazin
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  2. Claire L. Ihle
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  3. Philip Owens
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  4. Maureen E. Lynch
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BS: Conception, writing, editing

CI: Writing, editing

PO: Conception, writing, editing

ML: Conception, writing, editing

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Correspondence to Maureen E. Lynch.

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Sarazin, B.A., Ihle, C.L., Owens, P. et al. Mechanobiology of Bone Metastatic Cancer. Curr Osteoporos Rep 19, 580–591 (2021). https://doi.org/10.1007/s11914-021-00704-9

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