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Comparison study of chitosan/β-cyclodextrin and carboxymethyl chitosan/β-cyclodextrin microspheres

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Wuhan University Journal of Natural Sciences

Abstract

To compare two microspheres of chitosan/β-cyclodextrin and carboxymethyl chitosan/β-cyclodextrin loaded theophylline as pulmonary sustained drug delivery carriers, the characteristics and ciliotoxicity were studied. The drug loadings of chitosan/β-cyclodextrin and carboxymethyl chitosan/β-cyclodextrin microspheres were 21.09% and 21.42%, and the encapsulation efficiencies were 91.40% and 92.80%. The distributions of 50% (d 0.5) of chitosan/β-cyclodextrin and carboxymethyl chitosan/β-cyclodextrin microspheres were 4.89 and 5.83 μm, respectively. Both microspheres showed spherical shape with smooth or wrinkled surfaces. FT-IR of chitosan/β-cyclodextrin microspheres demonstrated that theophylline had formed hydrogen bonds with chitosan and β-cyclodextrin, while for the carboxymethyl chitosan/β-cyclodextrin microspheres theophylline had interaction with carboxymethyl chitosan. The moisture absorption showed that an equilibrium was reached within 24 h. The two microspheres possessed better adaptability. In vitro release of theophylline from chitosan/β-cyclodextrin microspheres was slower than that from carboxymethyl chitosan/β-cyclodextrin microspheres at pH 6.8.

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Authors and Affiliations

  1. Department of Basic Medicine, Weifang Medical University, Weifang, 261053, Shandong, China

    Ruobao Li, Chunling Zhao, Weifen Zhang, Lihong Shi & Jinbao Tang

  2. Shandong Provincial Key Laboratory of Applied Pharmacology, Weifang Medical University, Weifang, 261053, Shandong, China

    Weifen Zhang

Authors
  1. Ruobao Li
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  2. Chunling Zhao
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  3. Weifen Zhang
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  4. Lihong Shi
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  5. Jinbao Tang
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Corresponding author

Correspondence to Weifen Zhang.

Additional information

Foundation item: Supported by the Natural Science Foundation of Shandong Province (Y2007C044 and Y2008F15) and Scientific and Technological Brainstorm Project of Shandong Province (2008GG10002022)

Biography: LI Ruobao(1968–), male, Associate professor, research direction: foundation research of respiratory system.

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Li, R., Zhao, C., Zhang, W. et al. Comparison study of chitosan/β-cyclodextrin and carboxymethyl chitosan/β-cyclodextrin microspheres. Wuhan Univ. J. Nat. Sci. 14, 362–368 (2009). https://doi.org/10.1007/s11859-009-0415-2

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  • DOI: https://doi.org/10.1007/s11859-009-0415-2

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