Experimental study on the effect of moxibustion at Shenque (CV 8) for long-term exercise-induced fatigue

Abstract

Objective

To investigate the effect of moxibustion at Shenque (CV 8) on fatigue in rats with chronic exercise-induced exhaustion.

Methods

Thirty male Sprague-Dawley (SD) rats were randomly divided into a blank group, a model group and a moxibustion group, 10 rats in each group. Except rats in the blank group, the remaining rats were subjected to create long-term exhaustion models by repeated swimming. After successful modeling, rats in the moxibustion group received mild moxibustion at Shenque (CV 8) for 15 min, once every other day with a total of 10 times. Rats in the model group and the blank group did not receive moxibustion. At the end of the treatment, the exhausted times, and the body weight of rats before and after the experiment were compared among groups. The levels of blood malondialdehyde (MDA) and urea nitrogen (BUN), as well as the activities of aspartate transarninase (AST), alanine aminotransferase (ALT) and lactate dehydrogenase (LDH) were also measured by the automatic biochemical analyzer, 24 h after the exhausting excise.

Results

The 10th swimming time was significantly longer in the moxibustion group than that in the model group (P<0.01). The increase rate of the body weight was lower in the rats of the moxibustion group than that in the model group before the 7th and the 10th exhausting excise (P<0.05, P<0.01). The levels of serum MDA and BUN, as well as the activities of AST, ALT and LDH in the model group were higher than those in the blank group (all P<0.01). The levels of serum MDA and BUN, as well as the activities of AST, ALT and LDH in the moxibustion group were lower than those in the model group (P<0.01).

Conclusion

Moxibustion at Shenque (CV 8) can decrease the serum levels of MDA and BUN, as well as activities of AST, ALT and LDH in the long-term fatigue rats, thus to improve the symptoms of fatigue.

摘要

目的

探讨艾灸神阙穴对长期力竭大鼠抗疲劳性运动作用的影响。

方法

将30只Sprague-Dawley(SD)雄性大鼠随机分为空白组、模型组和艾灸组, 每组10只。除空白组外, 其余大鼠采用反复游泳实验制造长期力竭模型。造模成功后, 艾灸组大鼠温和灸神阕穴15 min, 隔日1次, 共治疗10次。模型组和空白组大鼠不接受治疗。治疗结束后比较各组大鼠的力竭时间及实验前后的体质量, 并采用全自动分析仪检测力竭运动24 h后血清中丙二醛(MDA)、血尿素氮(BUN)浓度及天门冬氨酸转氨酶(AST)、丙氨酸转氨酶(ALT)和乳酸脱氢酶(LDH)活性。

结果

第10次游泳时间比较, 艾灸组明显较模型组长(P<0.01)。艾灸组大鼠第7次、第10次力竭运动前体质量增长速度慢于同期模型组(P<0.05, P<0.01)。模型组大鼠血清MDA和BUN含量及AST、ALT和LDH活性均较空白组升高(均P<0.01)。艾灸组大鼠血清MDA和BUN含量及AST、ALT和LDH活性均较模型组降低(P<0.01)。

结论

艾灸神阙穴可以降低长期疲劳大鼠血清中的MDA和BUN含量及AST、ALT和LDH活性, 改善疲劳症状。