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Metabolic Changes Up to 10 years After Gastric Bypass

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Abstract

Objective

The aim of this study was to investigate the lipid and glycemic profiles of patients up to 10 years after Roux-en-Y gastric bypass.

Method

A retrospective, longitudinal study was conducted at a multidisciplinary center for the treatment of obesity in the state of São Paulo, Brazil. The study included 150 patients submitted to unbanded laparoscopic Roux-en-Y gastric bypass. The metabolic profile included total cholesterol and fractions, triglycerides, and fasting glucose. The patients were examined before and 3, 6, 12, 24, 48, 72, 96, and 120 months after surgery. Statistical analyses included the generalized estimating equations (GEE) and the Wilcoxon test at a significance level of 5%.

Results

All postoperative fasting glucose, total cholesterol, and triglyceride (p < 0.0001) test results were significantly lower than the preoperative test results. Low-density lipoprotein cholesterol (LDL-c) differed significantly in all but the 120-month follow-up (p = 0.0129). High-density lipoprotein cholesterol (HDL-c) was significantly higher 12, 24, 48, and 72 months after surgery (p < 0.001) and also 120 months after surgery (p = 0.0002).

Conclusion

Gastric bypass promoted the control of metabolic diseases inherent to obesity as long as 10 years after surgery.

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Author information

Authors and Affiliations

  1. Graduate Program in Health Sciences, Puc-Campinas, Campinas, SP, Brazil

    Daniela Vicinansa Mônaco-Ferreira

  2. Graduate Program in Health Sciences and of the School of Nutrition, Puc-Campinas, Campinas, SP, Brazil

    Vânia Aparecida Leandro-Merhi

  3. Lane Clinic, Campinas, SP, Brazil

    Nilton César Aranha, Andre Brandalise & Nelson Ary Brandalise

Authors
  1. Daniela Vicinansa Mônaco-Ferreira
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  2. Vânia Aparecida Leandro-Merhi
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  3. Nilton César Aranha
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  4. Andre Brandalise
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  5. Nelson Ary Brandalise
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Contributions

All authors contributed equally to data collection and analysis and manuscript writing and review.

Corresponding author

Correspondence to Vânia Aparecida Leandro-Merhi.

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Conflicts of Interest

The authors declare that they have no conflicts of interest.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed Consent

Does not apply. For this type of study, formal consent is not required.

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Mônaco-Ferreira, D.V., Leandro-Merhi, V.A., Aranha, N.C. et al. Metabolic Changes Up to 10 years After Gastric Bypass. OBES SURG 28, 1636–1642 (2018). https://doi.org/10.1007/s11695-017-3064-0

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  • DOI: https://doi.org/10.1007/s11695-017-3064-0

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