The Change in the Dumping Syndrome Concept
The previous paper discusses a further tactic in the treatment of the dumping syndrome using verapamil and acarbose .
Dumping was a frequent problem in the 1950s and 1960s, when duodenal ulcer was much more common. Operations that included a loss of pyloric regulatory function, such as gastric resection (with gastric bypass) or a pyloroplasty (with vagotomy), were common. These operations were occasionally followed by postprandial sweating, flushing, dizziness, weakness, tachycardia, palpitations, nausea, cramps, and loose stools of varying severity. These symptoms often abated with time .
The earlyphase, occurring about 15 min p.c., was attributed to rapid entrance of hyperosmotic foods (especially simple sugars) to the jejunum, where jejunal distension with passage of isotonic fluid from the plasma into the intestinal lumen occurred to achieve near-isotonic content. This action resulted in a fall in blood volume and thus significant sympathetic stimulation from various...
KeywordsDumping syndrome Gastric bypass GLP-1 Serotonin Hypoglycemia Acarbose Nesidioblastosis Gastric band
- 1.Moreira RO, Moreira RBM, Machado NAM, et al. Post-prandial hypoglycemia after bariatric surgery pharmacological treatment with verapamil and acarbose. Obes Surg 2008; 18. doi: 10.1007/s11695-008-9569-9.
- 3.Matthews DH, Lawrence W Jr, Poppell JW, et al. Change in effective volume during experimental dumping syndrome. Surgery 1960;48:185–94.Google Scholar