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Management of Hepatic Angiomyolipoma

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Journal of Gastrointestinal Surgery Aims and scope

Abstract

Preoperative diagnosis of hepatic angiomyolipoma is difficult, and the treatment for it remains controversial. The aim of this study is to review our experience in the treatment of hepatic angiomyolipoma and to propose a treatment strategy for this disease. We retrospectively collected the clinical, imaging, and pathological features of patients with hepatic angiomyolipoma. Immunohistochemical studies with antibodies for HMB-45, actin, S-100, cytokeratin, vimentin, and c-kit were performed. Treatment experience and long-term follow-up results are summarized. During a period of 9 years, 10 patients with hepatic angiomyolipoma were treated at our hospital. There was marked female predominance (nine patients). Nine patients received surgical resection without complications. One patient received nonoperative management with biopsy and follow-up. One patient died 11 months after surgery because of recurrent disease. We propose all symptomatic patients should receive surgical resection for hepatic angiomyolipoma. Conservative management with close follow-up is suggested in patients with asymptomatic tumors and meet the following criteria: (1) tumor size smaller than 5 cm, (2) angiomyolipoma proved through fine needle aspiration biopsy, (3) patients with good compliance, and (4) not a hepatitis virus carrier.

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Acknowledgements

The authors would like to thank Dr. Kao-Lung Liu (Department of Radiology, National Taiwan University Hospital) for assistance with Fig. 1 and interpretation of radiologic pictures.

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Authors and Affiliations

  1. Department of Surgery, National Taiwan University Hospital, and National Taiwan University College of Medicine, No. 7 Chung-Shan South Road, Taipei, 100, Taiwan

    Ching-Yao Yang, Ming-Chih Ho, Rey-Heng Hu, Yao-Ming Wu & Po-Huang Lee

  2. Department of Traumatology, National Taiwan University Hospital, and National Taiwan University College of Medicine, Taipei, 100, Taiwan

    Ching-Yao Yang

  3. Department of Pathology, National Taiwan University Hospital, and National Taiwan University College of Medicine, Taipei, 100, Taiwan

    Yung-Ming Jeng

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  1. Ching-Yao Yang
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  2. Ming-Chih Ho
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  5. Yao-Ming Wu
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Correspondence to Po-Huang Lee.

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Yang, CY., Ho, MC., Jeng, YM. et al. Management of Hepatic Angiomyolipoma. J Gastrointest Surg 11, 452–457 (2007). https://doi.org/10.1007/s11605-006-0037-3

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