Skip to main content
SpringerLink
Log in

Usefulness of FDG PET for diagnosis and radiotherapy of the patient with malignant lymphoma involving bone marrow

  • CASE REPORT
  • Published:
Radiation Medicine Aims and scope Submit manuscript

Abstract

We experienced a case of relapsed malignant lymphoma with multiple bone marrow or bone lesions. The case was diagnosed as follicular lymphoma by cytological biopsy of the right iliac bone, with 67Ga scintigraphy showing abnormal, intense uptake in multiple bones. After about 10 months of systemic chemotherapy, a relapse was suspected because of pain in the bilateral legs and a high level of lactate dehydrogenase. Assessment of the lesions in the patient was difficult by computed tomography because the affected sites were localized mainly in the bone marrow. 18F-Fluorodeoxyglucose (FDG) positron emission tomography (PET) was useful for detecting accurately the relapse sites in the bone marrow and enabled us to determine the field for radiotherapy. There are only a few reports of FDG-PET findings for such bone marrow malignant lymphomas. Therefore, we report the findings of FDG-PET for this case and review some of the literature about bone marrow lymphomas.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. R Bar-Shalom N Yefremov N Haim EJ Dann R Epelbaum Z Keidar et al. (2003) ArticleTitleCamera-based FDG PET and 67Ga SPECT in evaluation of lymphoma: comparative study Radiology 227 353–60 Occurrence Handle12637679 Occurrence Handle10.1148/radiol.2272020195

    Article  PubMed  Google Scholar 

  2. EV Dizendorf BG Baumert GK von Schulthess UM Lutolf HC Steinert (2003) ArticleTitleImpact of whole-body 18F-FDG PET on staging and managing patients for radiation therapy J Nucl Med 44 24–9 Occurrence Handle12515872

    PubMed  Google Scholar 

  3. U Metser O Goor H Lerman E Naparstek E Even-Sapir (2004) ArticleTitlePET-CT of extranodal lymphoma AJR Am J Roentgenol 182 1579–86 Occurrence Handle15150013

    PubMed  Google Scholar 

  4. AJCC cancer staging manual. 6th edition. Berlin: Springer; 2001. p. 393–403

  5. InstitutionalAuthorNameThe Non-Hodgkin's Lymphoma Classification Project (1997) ArticleTitleA clinical evaluation of the International Lymphoma Study Group classification of non-Hodgkin's lymphoma Blood 89 3909–18

    Google Scholar 

  6. P Lu (2005) ArticleTitleStaging and classification of lymphoma Semin Nucl Med 35 160–4 Occurrence Handle16098289 Occurrence Handle10.1053/j.semnuclmed.2005.02.002

    Article  PubMed  Google Scholar 

  7. InstitutionalAuthorNameThe International Non-Hodgkin's Lymphoma Prognostic Factors Project (1993) ArticleTitleA predictive model for aggressive non-Hodgkin's lymphoma N Engl J Med 329 987–94 Occurrence Handle10.1056/NEJM199309303291402

    Article  Google Scholar 

  8. J Romaguera P Mclaughlin L North D Dixon KB Silvermintz LA Garnsey et al. (1991) ArticleTitleMultivariate analysis of prognostic factors in stage IV follicular low-grade lymphoma: a risk model J Clin Oncol 9 762–9 Occurrence Handle1707956 Occurrence Handle1:STN:280:DyaK3M3gt1ajsg%3D%3D

    PubMed  CAS  Google Scholar 

  9. P Solal-Celigny P Roy P Colombat J White JO Armitage R Arranz-Saez et al. (2004) ArticleTitleFollicular lymphoma international prognostic index Blood 104 1258–65 Occurrence Handle15126323 Occurrence Handle10.1182/blood-2003-12-4434 Occurrence Handle1:CAS:528:DC%2BD2cXnt1ekuro%3D

    Article  PubMed  CAS  Google Scholar 

  10. YH Park S Kim SJ Choi BY Ryoo SH Yang GJ Cheon et al. (2005) ArticleTitleClinical impact of whole-body FDG-PET for evaluation of response and therapeutic decision-making of primary lymphoma of bone Ann Oncol 16 1401–2 Occurrence Handle15870088 Occurrence Handle10.1093/annonc/mdi234 Occurrence Handle1:STN:280:DC%2BD2MzotFamtA%3D%3D

    Article  PubMed  CAS  Google Scholar 

  11. F Moog M Bangerter CG Diederichs A Guhlmann E Merkle N Frickhofen et al. (1998) ArticleTitleExtranodal malignant lymphoma: detection with FDG PET versus CT Radiology 206 475–81 Occurrence Handle9457202 Occurrence Handle1:STN:280:DyaK1c7hvVCjtA%3D%3D

    PubMed  CAS  Google Scholar 

  12. S Wohrer U Jaeger K Kletter A Becherer A Hauswirth K Turetschek et al. (2006) ArticleTitle 18F-fluoro-deoxy-glucose positron emission tomography (18F-FDG-PET) visualizes follicular lymphoma irrespective of grading Ann Oncol 17 780–4 Occurrence Handle16497824 Occurrence Handle10.1093/annonc/mdl014 Occurrence Handle1:STN:280:DC%2BD283jtVKltA%3D%3D

    Article  PubMed  CAS  Google Scholar 

  13. M Hoffmann A Chott A Puspok U Jager K Kletter M Raderer (2004) ArticleTitle18F-fluorodeoxyglucose positron emission tomography (18F-FDG-PET) does not visualize follicular lymphoma of the duodenum Ann Hematol 83 276–8 Occurrence Handle15060746 Occurrence Handle10.1007/s00277-004-0889-0 Occurrence Handle1:CAS:528:DC%2BD2cXnvVyntLk%3D

    Article  PubMed  CAS  Google Scholar 

  14. H Asakura T Togami M Mitani H Takashima K Yokoe Y Yamamoto et al. (2005) ArticleTitleUsefulness of FDG-PET imaging for the radiotherapy treatment planning of pyothorax-associated lymphoma Ann Nucl Med 19 725–8 Occurrence Handle16445000 Occurrence Handle10.1007/BF02985123

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Radiology, National Center for Geriatrics and Gerontology, 36-3 Gengo, Morioka-cho, Ohbu, 474-8522, Japan

    Takashi Nihashi, Kazumasa Hayasaka, Takashi Sobajima & Rikio Kato

  2. Department of Hematology, National Center for Geriatrics and Gerontology, Ohbu, Japan

    Toshihide Itou

  3. Department of Brain Science and Molecular Imaging, National Institute for Longevity Sciences, Aichi, Japan

    Kengo Ito

  4. Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Japan

    Yoshiyuki Ito, Takeo Ishigaki & Shinji Naganawa

Authors
  1. Takashi Nihashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kazumasa Hayasaka
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Toshihide Itou
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Takashi Sobajima
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Rikio Kato
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Kengo Ito
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Yoshiyuki Ito
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Takeo Ishigaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Shinji Naganawa
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Takashi Nihashi.

About this article

Cite this article

Nihashi, T., Hayasaka, K., Itou, T. et al. Usefulness of FDG PET for diagnosis and radiotherapy of the patient with malignant lymphoma involving bone marrow. Radiat Med 25, 130–134 (2007). https://doi.org/10.1007/s11604-006-0110-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11604-006-0110-6

Key words

Search

Navigation