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Correlation Between Aquaporin 4 Expression and Different DWI Parameters in Grade I Meningioma

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Abstract

Purpose

Diffusion-weighted imaging (DWI) measures water diffusion in biological tissues. Cellular water transport depends on aquaporins (AQPs). The expression of aquaporins might differ in several pathologic disorders. Therefore, the aim of this study was to evaluate the associations between AQP4 expression and different DWI parameters in meningioma.

Procedures

Twenty-three patients with meningioma grade I were included in this retrospective study. DWI was obtained with three b values (0; 500; 1000) using a 1.5-T device. ADCmean, ADCmin, ADCmax, and true diffusion coefficients (D) were obtained in every patient. Aquaporin 4 expression was quantified immunohistochemically in four immunoreactivity levels.

Results

The estimated DWI parameters (mean value ± standard deviation, 10−3 mm2 s−1) of the tumors were as follows: ADCmin 0.67 ± 0.16, ADCmean 0.94 ± 0.23, ADCmax 1.29 ± 0.50, and D 0.65 ± 0.23. The mean level of the AQP4 expression was 2.02 ± 0.75 points. A statistically significant correlation between AQP4 expression and ADCmax was identified (r = 0.508, p = 0.013). No significant correlations between AQP4 and other DWI parameters were found.

Conclusions

A clear correlation between AQP4 expression and ADCmax values in grade I meningioma was identified. There were no significant correlations between AQP4 expression and other DWI parameters, such as ADCmin, ADCmean, and D.

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Authors and Affiliations

  1. Department of Neuroradiology, University Hospital of Leipzig, Liebigstraße 20, 04103, Leipzig, Germany

    Stefan Schob

  2. Department of Radiology, University Hospital of Leipzig, Liebigstraße 20, 04103, Leipzig, Germany

    Alexey Surov, Hans Jonas Meyer & Rolf Peter Spielmann

  3. Institute of Medical Epidemiology, Biometry, and Statistics, Martin-Luther-University Halle-Wittenberg, Halle, Germany

    Andreas Wienke

  4. Department of Dermatology and Pathology, Martin-Luther-University Halle-Wittenberg, Halle, Germany

    Eckhard Fiedler

Authors
  1. Stefan Schob
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  2. Alexey Surov
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  3. Andreas Wienke
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  4. Hans Jonas Meyer
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  5. Rolf Peter Spielmann
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  6. Eckhard Fiedler
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Corresponding author

Correspondence to Stefan Schob.

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This study was approved by the institutional review board.

Conflict of Interest

The authors declare that they have no conflict of interest.

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Additional information

Stefan Schob and Alexey Surov contributed equally to the paper

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Schob, S., Surov, A., Wienke, A. et al. Correlation Between Aquaporin 4 Expression and Different DWI Parameters in Grade I Meningioma. Mol Imaging Biol 19, 138–142 (2017). https://doi.org/10.1007/s11307-016-0978-1

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  • DOI: https://doi.org/10.1007/s11307-016-0978-1

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