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A comparison of homogeneous and biphasic hydrogenation systems of macrocyclic lactones with in situ formed rhodium complexes

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Abstract

Homogeneous and biphasic hydrogenation of avermectins catalyzed by rhodium complexes in situ formed from [RhCl(COD)]2 and triphenylphosphine or sulphonated arylphosphines, respectively, was studied under mild reaction conditions. Effects of adding TBAB and bis-QACs as phase transfer agents, Tween® 80 as non-ionic surfactant, β-cyclodextrin as inverse phase-transfer agent, and triphenylphosphine as co-ligand, are reported for the biphasic system.

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Authors and Affiliations

  1. Instituto de Desarrollo Tecnológico para la Industria Química, INTEC (UNL, CONICET), Güemes 3450, 3000, Santa Fe, Argentina

    María I. Cabrera, Patricia D. Zgolicz & Ricardo J. Grau

Authors
  1. María I. Cabrera
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  2. Patricia D. Zgolicz
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  3. Ricardo J. Grau
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Correspondence to Ricardo J. Grau.

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Cabrera, M.I., Zgolicz, P.D. & Grau, R.J. A comparison of homogeneous and biphasic hydrogenation systems of macrocyclic lactones with in situ formed rhodium complexes. React Kinet Catal Lett 93, 175–185 (2008). https://doi.org/10.1007/s11144-007-5216-z

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  • DOI: https://doi.org/10.1007/s11144-007-5216-z

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