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Mechanisms of Rutin Pharmacological Action (Review)

  • Molecular-Biological Problems of Drug Design and Mechanism of Drug Action
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Pharmaceutical Chemistry Journal Aims and scope

The pharmacological properties and mechanisms of action of the flavanoid rutin were reviewed. Rutin can interact with free radicals and various protein systems to exhibit antioxidant, anti-inflammatory, anti-allergy, and antitumor activity. At present, much research is devoted to studies of the mechanisms of rutin pharmacological action.

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References

  1. J. A. Ross and C. M. Kasum, Annu. Rev. Nutr., 22, 19 – 34 (2002).

    Article  CAS  PubMed  Google Scholar 

  2. V. Cody, Prog. Clin. Biol. Res., 280 – 282 (1988).

  3. J. Cao, Y. Zhang, W. Chen, and X. Zhao, Br. J. Nutr., 103, 249 – 255 (2010).

    Article  CAS  PubMed  Google Scholar 

  4. S. H. Hakkien, S. O. Karenlampi, I. M. Heinonen, et al., J. Agric. Food Chem., 47, 2274 – 2279 (1999).

    Article  Google Scholar 

  5. S. Scholz and G. Williamson, Int. J. Vitam. Nutr. Res., 77, 224 – 235 (2007).

    Article  CAS  PubMed  Google Scholar 

  6. G. Williamson and C. Manach, Am. J. Clin. Nutr., 81, 243 – 255 (2005).

    Google Scholar 

  7. M. D. Mashkovskii, Drugs [in Russian], RIA Novaya Volna, Moscow (2007), pp. 629 – 631.

    Google Scholar 

  8. V. Crespy, C. Morand, C. Besson, et al., J. Agric. Food Chem., 50, 618 – 621 (2002).

    Article  CAS  PubMed  Google Scholar 

  9. S. Scholz and G. Williamson, Int. J. Vitam. Nutr. Res., 77, 224 – 235 (2007).

    Article  CAS  PubMed  Google Scholar 

  10. T. Walle, A. M. Browning, L. L. Steed, et al., J. Nutr., 135, 48 – 52 (2005).

    CAS  PubMed  Google Scholar 

  11. X. Chen, O. Q. P. Yin, Z. Zuo, and M. S. S. Chow, Pharm. Res., 22, 892 – 901 (2005).

    Article  CAS  PubMed  Google Scholar 

  12. B. A. Graf, C. Ameho, G. G. Dolnikowski, et al., J. Nutr., 136, 39 – 44 (2006).

    CAS  PubMed  Google Scholar 

  13. V. C. de Boer, A. A. Dihal, H. van der Woude, et al., J. Nutr., 135, 1718 – 1725 (2005).

    PubMed  Google Scholar 

  14. K. Azuma, K. Ippoushi, H. Ito, et al., Biosci. Biotechnol. Biochem., 67, 2548 – 2555 (2003).

    Article  CAS  PubMed  Google Scholar 

  15. M. Mamani-Matsuda, T. Kauss, A. Al-Kharrat, et al., Biochem. Pharmacol., 72,1304 – 1310 (2006).

    Article  CAS  PubMed  Google Scholar 

  16. D. A. Valerio, S. R. Georgetti, D. A. Magro, et al., J. Nat. Prod., 72, 1975 – 1979 (2009).

    Article  CAS  PubMed  Google Scholar 

  17. S. R. McAnulty, L. S. McAnulty, D. C. Nieman, et al., Appl. Physiol., Nutr., Metab., 33, 254 – 262 (2008).

    Article  CAS  Google Scholar 

  18. M. Inam, M. Altinisik, and M. D. Bilgin, Cell Biochem. Funct., 20, 291 – 296 (2002).

    Article  Google Scholar 

  19. I. Huk, V. Brovkovych, J. Nanobash Vili, et al., Br. J. Surg., 85, 1080 – 1085 (1998).

    Article  CAS  PubMed  Google Scholar 

  20. S. Das, A. K. Mandal, A. Ghosh, et al., Curr. Aging Sci., 1, 169 – 174 (2008).

    Article  CAS  PubMed  Google Scholar 

  21. A. Kahraman, N. Erkasap, and M. Serteser, J. Nephrol., 16, 219 – 224 (2003).

    CAS  PubMed  Google Scholar 

  22. A. M. Seufi, S. S. Ibrahim, and T. K. Elmaghraby, J. Exp. Clin. Cancer Res., 20, 80 (2009).

    Article  Google Scholar 

  23. C. V. DeWhalley, J. F. Rankin, S. M. Rankin, et al., Biochem. Pharmacol., 39, 1743 – 1749 (1990).

    Article  CAS  Google Scholar 

  24. J. F. Su, C. J. Guo, J. Y. Wei, et al., Biomed. Environ. Sci., 16, 1 – 8 (2003).

    PubMed  Google Scholar 

  25. S. Egert, C. Boesch-Saadatmandi, S. Wolffram, et al., J. Nutr., 140, 278 – 284 (2010).

    Article  CAS  PubMed  Google Scholar 

  26. S. Juzwiak, J. Wojcincki, K. Mokrzicki, et al., Pharmacol. Rep., 57, 604 – 609 (2005).

    CAS  PubMed  Google Scholar 

  27. L. Zhao, J. Wu, Y. Wang, et al., J. Agric. Food Chem., 59, 1104 – 1108 (2011).

    Article  CAS  PubMed  Google Scholar 

  28. Y. Yamamoto and E. Oue, Biosci. Biotechnol. Biochem., 70, 933 – 939 (2006).

    Article  CAS  PubMed  Google Scholar 

  29. F. Perez-Vizcaino, J. Duarte, R. Jimenez, et al., Pharmacol. Rep., 61, 67 – 75 (2009).

    Article  CAS  PubMed  Google Scholar 

  30. K. T. Calamia, Experiment Med. Biol., 44, 545 – 547 (2003).

    Google Scholar 

  31. W. W. Buss, D. E. Kopp, and E. Middleton, Allergy Clin. Immunol., 73, 801 – 809 (1984).

    Article  Google Scholar 

  32. H. P. Kim, I. Mani, and V. A. Ziboh, Prostaglandins Leukotrienes Essent. Fatty Acids, 58, 17 – 24 (1998).

    Article  CAS  Google Scholar 

  33. M. G. Ortega, A. C. Saragusti, J. L. Cabrera, and G. A. Chiabrando, Arch. Biochem. Biophys., 498, 105 – 110 (2010).

    Article  CAS  PubMed  Google Scholar 

  34. T. Yokoo and M. Kitamura, Am. J. Physiol., 273, 206 – 212 (1997).

    Google Scholar 

  35. J. Levy, I. Teuerstein, M. Marbach, et al., Biochem. Biophys. Res. Commun., 123, 1227 – 1233 (1984).

    Article  CAS  PubMed  Google Scholar 

  36. J. A. Boutin, Int. J. Biochem., 26, 1203 – 1226 (1994).

    Article  CAS  PubMed  Google Scholar 

  37. M. Joskova, S. Franova, and V. Sadlonova, Bratisl. Lek. Listy, 112, 9 – 12 (2011).

    CAS  PubMed  Google Scholar 

  38. H. Moon, H. H. Choi, J. Y. Lee, et al., Arch. Pharm. Res., 31, 771 – 778 (2008).

    Article  CAS  PubMed  Google Scholar 

  39. A. P. Rogerio, C. L. Dora, E. L. Andrade, et al., Pharmacol. Res., 61, 288 – 297 (2010).

    Article  CAS  PubMed  Google Scholar 

  40. C. C. Chuang, K. Martinez, G. Xie, et al., Am. J. Clin. Nutr., 92, 1511 – 1521 (2010).

    Article  CAS  PubMed  Google Scholar 

  41. R. Vidya Priadarsini, R. Senthil Murugan, S. Maitreyi, et al., Eur. J. Pharmacol., 649, 84 – 91 (2010).

    Article  Google Scholar 

  42. R. L. Sighal, Y. A. Yeh, N. Prajda, et al., Biochem. Biophys. Res. Commun., 208, 425 – 431 (1995).

    Article  Google Scholar 

  43. M. Yoshida, M. Yamamoto, and T. Nikaido, Cancer Res., 52, 6676 – 6681 (1992).

    CAS  PubMed  Google Scholar 

  44. M. Yoshida, T. Sakai, N. Hosokawa, et al., FEBS Lett., 260, 10 – 13 (1990).

    Article  CAS  PubMed  Google Scholar 

  45. G. Sliutz, J. Karlseder, C. Tempfer, et al., Br. J. Cancer, 74, 172 – 177 (1996).

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  46. R. Aalinkeel, B. Bundukumar, J. L. Reynolds, et al., Prostate, 68, 1773 – 1789 (2008).

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  47. S. H. Kim, G. S. Yeo, Y. S. Lim, et al., Exp. Mol. Med., 30, 87 – 92 (1998).

    Article  CAS  PubMed  Google Scholar 

  48. S. L. Hsiu, Y. C. Hou, Y. H. Wang, et al., Life Sci., 72, 227 – 235 (2002).

    Article  CAS  PubMed  Google Scholar 

  49. Y. Chen, P. Xiao, D. S. Ou-Yang, et al., Clin. Exp. Pharmacol. Physiol., 36,828 – 833 (2009).

    Article  CAS  PubMed  Google Scholar 

  50. R. Cermak, S. Wein, S. Wolffram, and P. Langguch, Eur. J. Pharm. Sci., 38, 519 – 524 (2009).

    Article  CAS  PubMed  Google Scholar 

  51. J. S. Choi, Y. J. Piao, and K. W. Kang, Arch. Pharmacal Res., 34, 607 – 613 (2011).

    Article  CAS  Google Scholar 

  52. J. S. Choi and H. K. Han, J. Pharm. Pharmacol. 56, 1537 – 1542 (2004).

    CAS  Google Scholar 

  53. Y. H. Wang, P. D. Chao, S. L. Hsiu, et al., Clin. Exp. Pharmacol. Physiol., 74, 1191 – 1197 (2004)

    CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Sechenov First Moscow State Medical University, Moscow, 119991, Russia

    I. V. Koval’skii, I. I. Krasnyuk, I. I. Krasnyuk Jr., O. I. Nikulina, A. V. Belyatskaya, Yu. Ya. Kharitonov, N. B. Feldman & S. V. Lutsenko

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  1. I. V. Koval’skii
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  2. I. I. Krasnyuk
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  3. I. I. Krasnyuk Jr.
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  4. O. I. Nikulina
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  5. A. V. Belyatskaya
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  6. Yu. Ya. Kharitonov
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 48, No. 2, pp. 3 – 6, February, 2014.

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Koval’skii, I.V., Krasnyuk, I.I., Krasnyuk, I.I. et al. Mechanisms of Rutin Pharmacological Action (Review). Pharm Chem J 48, 73–76 (2014). https://doi.org/10.1007/s11094-014-1050-6

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  • DOI: https://doi.org/10.1007/s11094-014-1050-6

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