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A catalyst-free approach to synthesis of spiroacenaphthylene-pyranopyrazole derivatives in water media

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Abstract

A simple approach for the synthesis of spiroacenaphthylene-pyranopyrazole derivatives was achieved via the reaction between acenaphthoquinone, pyrazolones, and activated methylene compounds (malononitrile derivatives) in water as a green solvent without using any catalyst in order to avoid the use of transition metal. This method has the advantages of mild reaction condition, short reaction time, easy workup, excellent yields, and avoidance of environmentally hazardous solvents.

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  1. Department of Chemistry, Faculty of Science, Imam Khomeini International University, Qazvin, Iran

    Zeinab Amiri & Mohammad Bayat

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  1. Zeinab Amiri
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  2. Mohammad Bayat
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Correspondence to Mohammad Bayat.

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Amiri, Z., Bayat, M. A catalyst-free approach to synthesis of spiroacenaphthylene-pyranopyrazole derivatives in water media. Mol Divers 25, 121–129 (2021). https://doi.org/10.1007/s11030-019-10030-z

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  • DOI: https://doi.org/10.1007/s11030-019-10030-z

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