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Metabolic alterations in carcinoma ex pleomorphic adenoma development of lacrimal glands

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Abstract

Purpose

To evaluate metabolic alterations along with the carcinoma ex pleomorphic adneoma (CXPA) development of lacrimal glands (LG).

Methods

Four samples of the normal LG (NLG), 9 of pleomorphic adenoma (PA), 4 of residual PA (rPA), and 4 of CXPA of LG were included. GLUT-1, HIF-1α, FASN, and adipophilin by immunohistochemical stains were performed in the selected cases.

Results

Was observed higher expression of markers associated with glycolytic and lipid metabolism in the tumor tissue samples when compared to the NLG samples. Additionally, GLUT-1, FASN, and Adipophilin were more expressed in CXPA samples while HIF-1α in PA samples.

Conclusions

In conclusion, our results demonstrate overexpression of FASN and Adipophilin in CXPA which may reflect a metabolic shift toward lipogenesis in cancer cells.

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Acknowledgements

We would like to thank Ana Cláudia Sparapani Piazza and Arethusa Souza for their technical assistance. This study was supported by São Paulo Research Foundation (FAPESP), grant numbers 15/07304-0, 19/06809-2, 19/10788-0, and 19/09419-0 and by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil (CAPES)—Finance Code 001.

Funding

This study was supported by São Paulo Research Foundation (FAPESP), grant numbers 15/07304–0, 19/06809–2, 19/10788–0, and 19/09419–0 and by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil (CAPES)—Finance Code 001.

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Author notes

  1. Reydson Alcides de Lima-Souza and Natália de Magalhães Rodrigues are contributed equally to this study and should be considered as first authors

Authors and Affiliations

  1. Department of Oral Diagnosis, Piracicaba Dental School, State University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil

    Reydson Alcides de Lima-Souza & João Figueira Scarini

  2. Department of Pathology, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil

    Reydson Alcides de Lima-Souza, Natália de Magalhães Rodrigues, João Figueira Scarini, Erika Said Abu Egal, Albina Altemani & Fernanda Viviane Mariano

  3. Department of Surgery, Head and Neck Surgery, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil

    Mário Fernandez Sobral Silva & Alfio José Tincani

  4. Department of Pathology, School of Medicine, University of Utah (UU), Salt Lake City, UT, USA

    Erika Said Abu Egal

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  1. Reydson Alcides de Lima-Souza
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Contributions

Conceptualization was contributed by AA and FVM; Methodology was contributed by RALS, NMR, JFS, MFSS, AJT, and ESAE; Formal analysis and investigation were contributed by RALS, AA, and FVM; Writing—original draft preparation, was contributed by RALS, NMR; Writing—review and editing, was contributed by RALS, NMR, JFS, MFSS, AJT, ESAE, AA, and FVM; Funding acquisition was contributed by FVM; Resources were contributed by MFSS and AJT; Supervision was contributed by ESAE, AA, and FVM. All authors reviewed and approved the final manuscript.

Corresponding author

Correspondence to Fernanda Viviane Mariano.

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Conflicts of interest

The authors declare that they have no conflict of interests.

Data availability

The data that support the findings of this study are available from the corresponding author upon reasonable request.

Ethics approval

This study was approved by the Research Ethics Committee of the State University of Campinas (Protocol Number: 2.601.457).

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de Lima-Souza, R.A., Rodrigues, N.d., Scarini, J.F. et al. Metabolic alterations in carcinoma ex pleomorphic adenoma development of lacrimal glands. Int Ophthalmol 42, 1101–1109 (2022). https://doi.org/10.1007/s10792-021-02096-2

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  • DOI: https://doi.org/10.1007/s10792-021-02096-2

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