Subpopulation Structure of IFNγ-Producing T Lymphocytes in Patients with Pulmonary Tuberculosis
- 18 Downloads
The study of subpopulation structure of IFNγ-producing T cells in patients with pulmonary tuberculosis revealed a decrease in the number of CD3+ IFNγ+ cells against the background of significantly increased IFNγ secretion in vitro irrespective of the clinical form of the disease and drug sensitivity of M. tuberculosis, most strongly expressed in case of the disseminated tuberculosis. In patients with infiltrative drug-sensitive and drug-resistant pulmonary tuberculosis, increased number of Th1/Th17 lymphocytes (CD4+ IFNγ+IL-17A+) and, conversely, decreased number of blood γδT cells was detected.
Key WordsTh1/Th17 lymphocytes γδT lymphocytes IFNγ pulmonary tuberculosis
Unable to display preview. Download preview PDF.
- 2.Churina EG, Urazova OI, Novitskii VV, Esimova IE. Secondary immunological insufficiency in patients with pulmonary tuberculosis. Tomsk, 2013. Russian.Google Scholar
- 3.Griffiths KL, Pathan AA, Minassian AM, Sander CR, Beveridge NE, Hill AV, Fletcher HA, McShane H. Th1/Th17 cell induction and corresponding reduction in ATP consumption following vaccination with the novel Mycobacterium tuberculosis vaccine MVA85A. PLoS One. 2011;6(8):e23463. doi: https://doi.org/10.1371/journal.pone.0023463.CrossRefPubMedPubMedCentralGoogle Scholar
- 5.Meraviglia S, El Daker S, Dieli F, Martini F, Martino A. γδT cells cross-link innate and adaptive immunity in Mycobacterium tuberculosis infection. Clin. Dev. Immunol. 2011;2011. ID 587315. doi: https://doi.org/10.1155/2011/587315.
- 6.Nanke Y, Kobashigawa T, Yago T, Kawamoto M, Yamanaka H, Kotake S. Detection of IFN-g+IL-17+ cells in salivary glands of patients with Sjögren’s syndrome and Mikulicz’s disease: Potential role of Th17×Th1 in the pathogenesis of autoimmune diseases. Nihon Rinsho Meneki Gakkai Kaishi. 2016;39(5):473-477.CrossRefPubMedGoogle Scholar