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Bulletin of Experimental Biology and Medicine

, Volume 165, Issue 3, pp 311–314 | Cite as

Subpopulation Structure of IFNγ-Producing T Lymphocytes in Patients with Pulmonary Tuberculosis

  • T. E. Kononova
  • O. I. Urazova
  • V. V. Novitskii
  • I. E. Esimova
  • E. G. Churina
Article
  • 24 Downloads

The study of subpopulation structure of IFNγ-producing T cells in patients with pulmonary tuberculosis revealed a decrease in the number of CD3+ IFNγ+ cells against the background of significantly increased IFNγ secretion in vitro irrespective of the clinical form of the disease and drug sensitivity of M. tuberculosis, most strongly expressed in case of the disseminated tuberculosis. In patients with infiltrative drug-sensitive and drug-resistant pulmonary tuberculosis, increased number of Th1/Th17 lymphocytes (CD4+ IFNγ+IL-17A+) and, conversely, decreased number of blood γδT cells was detected.

Key Words

Th1/Th17 lymphocytes γδT lymphocytes IFNγ pulmonary tuberculosis 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • T. E. Kononova
    • 1
  • O. I. Urazova
    • 1
  • V. V. Novitskii
    • 1
  • I. E. Esimova
    • 1
  • E. G. Churina
    • 1
    • 2
  1. 1.Department of Pathophysiology, Siberian State Medical UniversityMinistry of Health of the Russian FederationTomskRussia
  2. 2.Laboratory of Translational and Cellular BiomedicineNational Research Tomsk State UniversityTomskRussia

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