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Subpopulation Structure of IFNγ-Producing T Lymphocytes in Patients with Pulmonary Tuberculosis

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Bulletin of Experimental Biology and Medicine Aims and scope

The study of subpopulation structure of IFNγ-producing T cells in patients with pulmonary tuberculosis revealed a decrease in the number of CD3+ IFNγ+ cells against the background of significantly increased IFNγ secretion in vitro irrespective of the clinical form of the disease and drug sensitivity of M. tuberculosis, most strongly expressed in case of the disseminated tuberculosis. In patients with infiltrative drug-sensitive and drug-resistant pulmonary tuberculosis, increased number of Th1/Th17 lymphocytes (CD4+ IFNγ+IL-17A+) and, conversely, decreased number of blood γδT cells was detected.

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Authors and Affiliations

  1. Department of Pathophysiology, Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia

    T. E. Kononova, O. I. Urazova, V. V. Novitskii, I. E. Esimova & E. G. Churina

  2. Laboratory of Translational and Cellular Biomedicine, National Research Tomsk State University, Tomsk, Russia

    E. G. Churina

Authors
  1. T. E. Kononova
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  2. O. I. Urazova
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  3. V. V. Novitskii
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  4. I. E. Esimova
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  5. E. G. Churina
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Corresponding author

Correspondence to T. E. Kononova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 165, No. 3, pp. 281-284, March, 2018

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Kononova, T.E., Urazova, O.I., Novitskii, V.V. et al. Subpopulation Structure of IFNγ-Producing T Lymphocytes in Patients with Pulmonary Tuberculosis. Bull Exp Biol Med 165, 311–314 (2018). https://doi.org/10.1007/s10517-018-4157-z

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  • DOI: https://doi.org/10.1007/s10517-018-4157-z

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