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Japanese Journal of Ophthalmology

, Volume 62, Issue 2, pp 163–167 | Cite as

Indocyanine green angiography findings of cystoid macular edema secondary to paclitaxel therapy

  • Nanami Nomi
  • Manami Ota
  • Miho Fukumura
  • Yoshihisa Nuno
  • Makoto Hatano
  • Makiko Wakuta
  • Ryoji YanaiEmail author
  • Kazuhiro Kimura
Clinical Investigation

Abstract

Purpose

To report 2 cases of paclitaxel-related maculopathy manifesting as cystoid macular edema (CME) with late petaloid hyperfluorescence on indocyanine green angiography (IA).

Cases

A 74-year-old man (patient 1) undergoing paclitaxel chemotherapy for gastric and metastatic liver cancer and a 69-year-old man (patient 2) receiving paclitaxel for hypopharyngeal cancer presented with anorthopia in both eyes. Spectral domain–optical coherence tomography (SD-OCT) revealed macular edema in both eyes of each patient. Fluorescein angiography showed weak petaloid pooling around the fovea in the late phase. IA revealed CME with petaloid hyperfluorescence that matched the region of macular edema detected by SD-OCT. The CME was attenuated in the right eye but not in the left eye of patient 1 at 2 weeks after discontinuation of paclitaxel treatment, whereas it was no longer apparent in either eye at 3 months. The CME was no longer detected in either eye of patient 2 at 3 months after discontinuation of paclitaxel.

Conclusion

These cases suggest that paclitaxel-induced CME may result from intraretinal accumulation of intracellular fluid and minimal impairment of the blood retinal barrier.

Keywords

Cystoid macular edema Indocyanine green angiography Maculopathy Paclitaxel 

Notes

Conflicts of interest

N. Nomi, None; M. Ota, None; M. Fukumura, None; Y. Nuno, None; M. Hatano, None; M. Wakuta, None; R. Yanai, None; K. Kimura, None.

References

  1. 1.
    Teitelbaum BA, Tresley DJ. Cystic maculopathy with normal capillary permeability secondary to docetaxel. Optom Vis Sci. 2003;80:277–9.CrossRefPubMedGoogle Scholar
  2. 2.
    Telander DG, Sarraf D. Cystoid macular edema with docetaxel chemotherapy and the fluid retention syndrome. Semin Ophthalmol. 2007;22:151–3.CrossRefPubMedGoogle Scholar
  3. 3.
    Baskin DE, Garg SJ. Abraxane-induced cystoid macular edema refractory to concomitant intravenous bevacizumab. Can J Ophthalmol. 2011;46:200–1.CrossRefPubMedGoogle Scholar
  4. 4.
    Ito S, Okuda M. A case of cystic maculopathy during paclitaxel therapy. J Jpn Ophthalmol Soc. 2010;114:23–7.Google Scholar
  5. 5.
    Smith SV, Benz MS, Brown DM. Cystoid macular edema secondary to albumin-bound paclitaxel therapy. Arch Ophthalmol. 2008;156:1605–6.CrossRefGoogle Scholar
  6. 6.
    Semb KA, Amandal S, Oilan P. Capillary protein leak syndrome appears to explain fluid retention in cancer patients who received docetaxel treatment. J Clin Oncol. 1998;16:3426–32.CrossRefPubMedGoogle Scholar
  7. 7.
    Wolter JR. The histopathology of cystoid macular edema. Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1981;216:85–101.CrossRefPubMedGoogle Scholar
  8. 8.
    Joshi MM, Garreston BR. Paclitaxel maculopathy. Arch Ophthalmol. 2007;125:709–10.CrossRefPubMedGoogle Scholar
  9. 9.
    Kuznetocova TI, Cech P, Herbort CP. The mystery of angiographically silent macular oedema due to taxanes. Int Ophthalmol. 2012;32:299–304.CrossRefGoogle Scholar

Copyright information

© Japanese Ophthalmological Society 2017

Authors and Affiliations

  • Nanami Nomi
    • 1
  • Manami Ota
    • 2
  • Miho Fukumura
    • 1
  • Yoshihisa Nuno
    • 1
  • Makoto Hatano
    • 3
  • Makiko Wakuta
    • 4
  • Ryoji Yanai
    • 3
    Email author
  • Kazuhiro Kimura
    • 3
  1. 1.Japan Community Health Care Organization (JCHO) Shimonoseki Medical CenterShimonosekiJapan
  2. 2.JA Shuto General HospitalYanaiJapan
  3. 3.Department of OphthalmologyYamaguchi University Graduate School of MedicineUbeJapan
  4. 4.Ube-Kohsan Central HospitalUbeJapan

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