Lasers in Medical Science

, Volume 34, Issue 9, pp 1897–1904 | Cite as

Photobiomodulation for the treatment of periodontal pockets in patients with type 2 diabetes: 1-year results of a randomized clinical trial

  • Nídia Castro dos Santos
  • Naira M. R. B. Andere
  • Manuela Maria Viana Miguel
  • Lúcio Murilo dos Santos
  • Milton SantamariaJr
  • Ingrid Fernandes Mathias
  • Maria Aparecida Neves Jardini
  • Mauro Pedrine SantamariaEmail author
Original Article


This study investigated the local effect of photobiomodulation (PBM) for the treatment of periodontal pockets in patients with periodontitis and type 2 diabetes. Thirty-eight periodontal pockets presenting probing depth (PD) and clinical attachment level (CAL) ≥ 5 mm were selected from 19 patients (two pockets/patient). The selected periodontal pockets were randomly assigned to receive mechanical debridement only (control group) or mechanical debridement with PBM (PBM group). Clinical measures, such as PD, CAL, bleeding on probing (BoP), and presence of supragingival biofilm (PI), were collected and compared at baseline, 3, 6, and 12 months. After 12 months, no statistically difference was observed for mean PD and mean CAL when control and PBM groups were compared. The frequency of pockets with PD 5–6 mm was significantly lower for the PBM group at 6 months when compared to the control group. Pockets with PD ≥ 7 mm changed significantly between baseline and 3, 6, and 12 months for the PBM group, while for the control group, statistical significance was only observed between baseline and 6 months. The PBM protocol used in this study did not provide significant changes for PD and CAL in periodontal pockets when compared to mechanical therapy only. However, PBM was more effective in reducing the percentage of moderate periodontal pockets at 6 months in patients with type 2 DM.


Diabetes mellitus Periodontitis Photobiomodulation Low-level laser therapy Periodontal pockets 


Compliance with ethical standards

Ethical approval

All procedures performed in study involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments.

Conflict of interest

The authors declare that they have no conflict of interest. This study did not receive any funding.

Declarations of interest



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Copyright information

© Springer-Verlag London Ltd., part of Springer Nature 2019

Authors and Affiliations

  • Nídia Castro dos Santos
    • 1
  • Naira M. R. B. Andere
    • 1
  • Manuela Maria Viana Miguel
    • 1
  • Lúcio Murilo dos Santos
    • 1
  • Milton SantamariaJr
    • 2
  • Ingrid Fernandes Mathias
    • 1
  • Maria Aparecida Neves Jardini
    • 1
  • Mauro Pedrine Santamaria
    • 1
    Email author
  1. 1.São Paulo State University (Unesp), Institute of Science and Technology, São José dos Campos, Department of Diagnosis and Surgery, Division of PeriodonticsSão José dos CamposBrazil
  2. 2.University of Araras (Uniararas), Dental School, Department of OrthodonticsArarasBrazil

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