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Effect of photobiomodulation adjunct to periodontal therapy on individuals with type 2 diabetes mellitus regarding periodontal clinical parameters: a systematic review and meta-analysis

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Abstract

The purpose of this study is to evaluate the scientific evidence on the impact of photobiomodulation adjunct to non-surgical periodontal treatment on individuals with type 2 diabetes mellitus (T2DM). The Preferred Reporting Items for Systematic Reviews and Meta-analyses statement was followed. A protocol was registered in the International Prospective Registry of Systematic Reviews (PROSPERO #CRD42022310756). The research was carried out in seven databases, with no restrictions regarding the year of publication. Our work included studies that compared periodontal clinical parameters among individuals undergoing non-surgical periodontal therapy associated with photobiomodulation and a control group of individuals undergoing non-surgical periodontal treatment. Study selection, data extraction, and risk of bias assessment (RoB 2.0) were performed by two review authors. Meta-analysis was performed. Mean difference (MD) and a 95% confidence interval (CI) were provided. Three hundred forty-one studies were identified, of which eight studies were included. The meta-analysis demonstrated that photobiomodulation adjunctive to periodontal therapy in individuals with diabetes resulted in a greater reduction in probing depth and greater attachment gain in comparison to periodontal treatment alone (p < 0.05). The included studies exhibited a low risk of bias. Photobiomodulation adjunct to periodontal therapy contributes to the improvement of periodontal clinical parameters in individuals with T2DM.

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The data that support the findings of this study are available upon reasonable request.

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Authors and Affiliations

  1. Periodontology Division, Department of Dental Clinics, Oral Pathology and Oral Surgery, School of Dentistry, Federal University de Minas Gerais, Antônio Carlos Avenue 6627, Pampulha, Belo Horizonte, Minas Gerais, 31270-901, Brazil

    Bárbara Lopes Freire, Fernando Oliveira Costa, Luís Otávio Miranda Cota & Rafael Paschoal Esteves-Lima

  2. Department of Child and Adolescent Oral Health, School of Dentistry, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, 31270-901, Brazil

    Lucas Guimarães Abreu

Authors
  1. Bárbara Lopes Freire
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  3. Fernando Oliveira Costa
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Contributions

Conceptualization: Bárbara Lopes Freire; Fernando Oliveira Costa; Luís Otávio Miranda Cota; Rafael Paschoal Esteves-Lima

Methodology: Bárbara Lopes Freire; Lucas Guimarães Abreu; Fernando Oliveira Costa; Luís Otávio Miranda Cota; Rafael Paschoal Esteves-Lima

Formal analysis and investigation: Bárbara Lopes Freire; Lucas Guimarães Abreu; Rafael Paschoal Esteves-Lima

Writing — original draft preparation: Bárbara Lopes Freire; Lucas Guimarães Abreu; Luís Otávio Miranda Cota; Rafael Paschoal Esteves-Lima

Writing — reviewing and editing: Lucas Guimarães Abreu; Fernando Oliveira Costa; Luís Otávio Miranda Cota; Rafael Paschoal Esteves-Lima

Visualization: Bárbara Lopes Freire; Lucas Guimarães Abreu; Fernando Oliveira Costa; Luís Otávio Miranda Cota; Rafael Paschoal Esteves-Lima

Supervision: Rafael Paschoal Esteves-Lima

Corresponding author

Correspondence to Rafael Paschoal Esteves-Lima.

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Appendix

Appendix

Table 4 Studies excluded after full text analysis and reasons for exclusion
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Freire, B.L., Abreu, L.G., Costa, F.O. et al. Effect of photobiomodulation adjunct to periodontal therapy on individuals with type 2 diabetes mellitus regarding periodontal clinical parameters: a systematic review and meta-analysis. Lasers Med Sci 38, 116 (2023). https://doi.org/10.1007/s10103-023-03782-6

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