Clinical Oral Investigations

, Volume 23, Issue 1, pp 285–292 | Cite as

Effect of photobiomodulation therapy on postoperative pain after endodontic treatment: a randomized, controlled, clinical study

  • Luana Pontes Barros Lopes
  • Fernando José Herkrath
  • Elizângela Cristina Barbosa Vianna
  • Erivan Clementino Gualberto Júnior
  • André Augusto Franco Marques
  • Emílio Carlos Sponchiado JúniorEmail author
Original Article



The aim of this prospective, randomized, clinical study was to assess the effect of photobiomodulation therapy (PBM) with low-level laser irradiation (LLLI) on postoperative pain after endodontic treatment.

Materials and methods

Sixty patients, diagnosed with irreversible pulpitis in lower molar teeth, participated in the study. All treatments were performed by a single operator. Participants were randomly divided into two groups: in the experimental group (EG), endodontic treatment was performed with a reciprocating system, immediately followed by PBM with LLLI; and only endodontic treatment was performed in the control group (CG). Postoperative pain was assessed by a second examiner, who was blinded, using two scales: verbal rating scale (VRS) and numerical rating scale (NRS). Assessment was carried out at 6, 12, and 24 h after treatment. Data were analyzed using chi-squared, Fisher’s exact, Mann-Whitney tests, ordinal, and non-parametric regression analyses.


For the prevalence of pain, the difference between the groups was significant for the evaluations performed after 6 h (p = 0.04) and 24 h (p = 0.02). The difference after 24 h remained significant after stratification by sex and extrusion of filling material. Increased pain intensity was associated with extrusion of root canal filling material to the periapical region in the two scales used.


The effect of PBM therapy after endodontic treatment showed a significant decreasein prevalence of postoperative pain.

Clinical relevance

The PBM reduces the prevalence of postoperative pain and may benefit patients who need endodontic treatment.


Clinical trial Intervention study Postoperative pain Photobiomodulation therapy 



No funding was received.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All the procedures were performed in accordance with the ethical standards of the Research Ethics Committee involving humans of the Federal University of Amazonas and the 1964 Declaration of Helsinki and its subsequent amendments or comparable ethical standards.

Informed consent

Written consent was obtained from all individuals who participated in this clinical trial.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Luana Pontes Barros Lopes
    • 1
  • Fernando José Herkrath
    • 1
  • Elizângela Cristina Barbosa Vianna
    • 1
  • Erivan Clementino Gualberto Júnior
    • 1
  • André Augusto Franco Marques
    • 1
  • Emílio Carlos Sponchiado Júnior
    • 1
    Email author
  1. 1.Dental school, Federal University of AmazonasManausBrazil

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