Abstract
Up to now, three distinct genotypes, A, B and C, of herpes simplex virus type 1 (HSV-1), based on polymorphisms in the US4 and US7 genes, have been reported. Here, we propose to include an additional polymorphism of the US2 gene. The refined genotyping method was validated using 423 clinical isolates from patients with different HSV-1 diseases. The proportions of three US2 genotypes were A, 46.6 %; B, 23.2 %; and C, 30.2 %. Genotype A of US2 and US4/US7 showed a highly significant correlation. In addition, the frequency of genotype A was significantly higher in women than in men with herpes labialis.
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The authors thank C. Rothmann and H. Urban for technical assistance and collection of viral isolates.
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Glück, B., Möbius, S., Pfaff, F. et al. Novel method for genotyping clinical herpes simplex virus type 1 isolates. Arch Virol 160, 2807–2811 (2015). https://doi.org/10.1007/s00705-015-2568-y
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DOI: https://doi.org/10.1007/s00705-015-2568-y