Archives of Virology

, Volume 153, Issue 8, pp 1621–1629 | Cite as

Recommendations for the classification of group A rotaviruses using all 11 genomic RNA segments

  • Jelle Matthijnssens
  • Max Ciarlet
  • Mustafizur Rahman
  • Houssam Attoui
  • Krisztián Bányai
  • Mary K. Estes
  • Jon R. Gentsch
  • Miren Iturriza-Gómara
  • Carl D. Kirkwood
  • Vito Martella
  • Peter P. C. Mertens
  • Osamu Nakagomi
  • John T. Patton
  • Franco M. Ruggeri
  • Linda J. Saif
  • Norma Santos
  • Andrej Steyer
  • Koki Taniguchi
  • Ulrich Desselberger
  • Marc Van Ranst
Virology Division News

Abstract

Recently, a classification system was proposed for rotaviruses in which all the 11 genomic RNA segments are used (Matthijnssens et al. in J Virol 82:3204–3219, 2008). Based on nucleotide identity cut-off percentages, different genotypes were defined for each genome segment. A nomenclature for the comparison of complete rotavirus genomes was considered in which the notations Gx-P[x]-Ix-Rx-Cx-Mx-Ax-Nx-Tx-Ex-Hx are used for the VP7-VP4-VP6-VP1-VP2-VP3-NSP1-NSP2-NSP3-NSP4-NSP5/6 encoding genes, respectively. This classification system is an extension of the previously applied genotype-based system which made use of the rotavirus gene segments encoding VP4, VP7, VP6, and NSP4. In order to assign rotavirus strains to one of the established genotypes or a new genotype, a standard procedure is proposed in this report. As more human and animal rotavirus genomes will be completely sequenced, new genotypes for each of the 11 gene segments may be identified. A Rotavirus Classification Working Group (RCWG) including specialists in molecular virology, infectious diseases, epidemiology, and public health was formed, which can assist in the appropriate delineation of new genotypes, thus avoiding duplications and helping minimize errors. Scientists discovering a potentially new rotavirus genotype for any of the 11 gene segments are invited to send the novel sequence to the RCWG, where the sequence will be analyzed, and a new nomenclature will be advised as appropriate. The RCWG will update the list of classified strains regularly and make this accessible on a website. Close collaboration with the Study Group Reoviridae of the International Committee on the Taxonomy of Viruses will be maintained.

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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Jelle Matthijnssens
    • 1
  • Max Ciarlet
    • 2
  • Mustafizur Rahman
    • 1
    • 3
  • Houssam Attoui
    • 4
  • Krisztián Bányai
    • 5
  • Mary K. Estes
    • 6
  • Jon R. Gentsch
    • 7
  • Miren Iturriza-Gómara
    • 8
  • Carl D. Kirkwood
    • 9
  • Vito Martella
    • 10
  • Peter P. C. Mertens
    • 4
  • Osamu Nakagomi
    • 11
  • John T. Patton
    • 12
  • Franco M. Ruggeri
    • 13
  • Linda J. Saif
    • 14
  • Norma Santos
    • 15
  • Andrej Steyer
    • 16
  • Koki Taniguchi
    • 17
  • Ulrich Desselberger
    • 18
  • Marc Van Ranst
    • 1
  1. 1.Laboratory of Clinical and Epidemiological Virology, Department of Microbiology and Immunology, Rega Institute for Medical ResearchUniversity of LeuvenLeuvenBelgium
  2. 2.Vaccine and Biologics—Clinical ResearchMerck & Co., Inc.North WalesUSA
  3. 3.Laboratory of Virology, ICDDR,B: MohakhaliDhakaBangladesh
  4. 4.Department of ArbovirologyInstitute for Animal HealthPirbrightUK
  5. 5.Veterinary Medical Research InstituteHungarian Academy of SciencesBudapestHungary
  6. 6.Departments of Molecular Virology, Microbiology, Medicine—GIBaylor College of MedicineHoustonUSA
  7. 7.Division of Viral DiseasesCDC, National Center for Immunization and Respiratory DiseasesAtlantaUSA
  8. 8.Enteric Virus Unit, Virus Reference DepartmentCentre for Infection, Health Protection AgencyLondonUK
  9. 9.Enteric Virus GroupMurdoch Childrens Research Institute, Royal Children HospitalVictoriaAustralia
  10. 10.Department of Public Health and Animal SciencesUniversity of BariBariItaly
  11. 11.Department of Molecular Microbiology and ImmunologyNagasaki UniversityNagasakiJapan
  12. 12.Laboratory of Infectious DiseasesNational Institute of Allergy and Infectious Diseases, National Institutes of HealthBethesdaUSA
  13. 13.Dipartimento di Sanità alimentare e animaleIstituto Superiore di SanitàRomeItaly
  14. 14.Food Animal Health Research Program, Ohio Agricultural Research and Development CenterThe Ohio State UniversityOhioUSA
  15. 15.Instituto de Microbiologia—UFRJRio de JanerioBrazil
  16. 16.Faculty of Medicine, Institute of Microbiology and ImmunologyUniversity of LjubljanaLjubljanaSlovenia
  17. 17.Department of Virology and ParasitologyFujita Health University School of MedicineToyoakeJapan
  18. 18.Department of MedicineUniversity of CambridgeCambridgeUK

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